Protein Kinases and their Inhibitors Implications in Modulating Disease Progression

Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents

“…prop-1-en-2-yl)benzamide (5). A suspension mixture of 4-(4fluorobenzylidene)-1,3-oxazol-5(4H)-one (0.14 g, 0.50 mmol), N-(diphenylmethylene)hydrazine (0.10 g, 0.50 mmol), and NaOAc (0.05 g, 0.55 mmol) in (20 mL) glacial acetic acid was heated to reflux on an oil bath for 24 h. After reaction accomplishment, the reaction mixture was concentrated to half volume, then cooled, and left overnight.…”

“…Cancer has remained a critical health issue around the world and is the second fatal cause after cardiovascular diseases. , Protein phosphorylation is among the most abundant and important cellular signaling post-translational modification in the biological system . This reversible enzymatic reaction plays a pivotal role in nearly all signal translational pathways and is carried out by a special class of proteins called protein kinases. , The functional annotation of this phosphorylation process in a growing number of human diseases and physiological conditions underscores the relevance of protein kinases in medicine. , Protein kinases catalyze the phosphorylation of target proteins by transferring the γ-phosphate group of adenosine triphosphate (ATP) onto the side-chain alcohol group of serine, threonine, and tyrosine amino acid residues . Misregulation of protein kinase signaling by kinase hyperactivation or mutation commonly results in human diseases including cancer .…”

“… 3 This reversible enzymatic reaction plays a pivotal role in nearly all signal translational pathways and is carried out by a special class of proteins called protein kinases. 4 , 5 The functional annotation of this phosphorylation process in a growing number of human diseases and physiological conditions underscores the relevance of protein kinases in medicine. 6 , 7 Protein kinases catalyze the phosphorylation of target proteins by transferring the γ-phosphate group of adenosine triphosphate (ATP) onto the side-chain alcohol group of serine, threonine, and tyrosine amino acid residues.…”