Protein Kinases and Pain

Funez, Mani Indiana; Souza, Fabiane Hiratsuka Veiga de; Pandossio, José Eduardo; Nascimento, Paulo Gustavo Barboni Dantas

doi:10.5772/38139

Cited by 2 publications

(2 citation statements)

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“…Nowadays, the development of protein kinase inhibitors for other therapeutic applications (e.g., pain, neurodegenerative disease) is emerging [ 6 ]. As reviewed by Funez et al in 2012, among potential targets involved in the physiopathology of pain, it is now well established that various protein kinases, such as PKA (protein kinase A), PKC (protein kinase C), p38 MAPK (p38 mitogen-activated protein kinase), ERK (extracellular signal-regulated kinase) or PKG (protein kinase G), are of high interest for pain management [ 7 ]. In addition, a recent review showed that protein kinases such as mTOR (mammalian target of rapamycin) and MNKs (MAPK-interacting kinases) could be targeted in order to manipulate translation regulation signaling for chronic pain treatment [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

et al. 2021

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The purpose of this review is to underline the protein kinases that have been established, either in fundamental approach or clinical trials, as potential biological targets in pain management. Protein kinases are presented according to their group in the human kinome: TK (Trk, RET, EGFR, JAK, VEGFR, SFK, BCR–Abl), CMGC (p38 MAPK, MEK, ERK, JNK, ASK1, CDK, CLK2, DYRK1A, GSK3, CK2), AGC (PKA, PKB, PKC, PKMζ, PKG, ROCK), CAMK, CK1 and atypical/other protein kinases (IKK, mTOR). Examples of small molecule inhibitors of these biological targets, demonstrating an analgesic effect, are described. Altogether, this review demonstrates the fundamental role that protein kinase inhibitors could play in the development of new pain treatments.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

et al. 2021

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“…Thus, numerous protein kinase inhibitors reached the market as anticancer drugs [5]. However, due to their pleiotropic role, protein kinases can be targeted for other application such as the treatment of pain [6][7][8]. It appears that some protein kinases are pivotal in the setting of central sensitization.…”

Section: Introductionmentioning

confidence: 99%