Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

Kovacs, Zsuzsa; Schacht, Teresa; Herrmann, Ann-Kathrin; Albrecht, Philipp; Lefkimmiatis, Konstantinos; Methner, Axel

doi:10.1042/bj20131198

Cited by 17 publications

(15 citation statements)

References 35 publications

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“…If the width of the histogram that gives the distribution of periods from the bootstrap calculation is narrow, the uncertainty in the derived period is low. For the sources that pass the above tests, we fit the light curves with a Fourier series (Kovacs & Kupi 2007). The Fourier parameters are similar to the light curves of classical Cepheids for P ∼ 3 − 15 days observed in the K-band (Persson et al 2004;Bhardwaj et al 2015).…”

Section: Results and Analysismentioning

confidence: 94%

“…To ensure that the shapes of the light curves are quantitatively similar to classical Cepheids, we compute their Fourier parameters, as well as the skewness and acuteness parameter, and visually inspect all the light curves. We have computed the Fourier parameters of our sources (Figure 3), following Kovacs & Kupi (2007). Out to fourth-order the Fourier series is expressed as:…”

Section: Results and Analysismentioning

confidence: 99%

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Clustered Cepheid Variables 90 Kiloparsecs From the Galactic Center

Chakrabarti

Saito

Quillen

et al. 2015

ApJ

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Distant regions close to the plane of our Galaxy are largely unexplored by optical surveys as they are hidden by dust. We have used near-infrared data (that minimizes dust obscuration) from the ESO Public survey VISTA Variables of the Via Lactea (VVV) (Minniti et al. 2011;Saito et al. 2012; henceforth S12) to search for distant stars at low latitudes. We have discovered four Cepheid variables within an angular extent of one degree centered at Galactic longitude of l = −27.4 • and Galactic latitude of b = −1.08 • . We use the tightly constrained period-luminosity relationship that these pulsating stars obey (Persson et al. 2004; Matsunaga et al. 2011) to derive distances. We infer an average distance to these Cepheid variables of 90 kpc. The Cepheid variables are highly clustered in angle (within one degree) and in distance (the standard deviation of the distances is 12 kpc). They are at an average distance of ∼ 2 kpc from the plane and their maximum projected separation is ∼ 1 kpc. These young (∼ 100 Myr old), pulsating stars (Bono et al. 2005) are unexpected at such large distances from the Galactic disk, which terminates at ∼ 15 kpc (Minniti et al. 2011). The highly clustered nature in distance and angle of the Cepheid variables suggests that the stars may be associated with a dwarf galaxy, one that was earlier predicted by a dynamical analysis (Chakrabarti & Blitz 2009).

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Section: Results and Analysismentioning

confidence: 94%

Section: Results and Analysismentioning

confidence: 99%

Clustered Cepheid Variables 90 Kiloparsecs From the Galactic Center

Chakrabarti

Saito

Quillen

et al. 2015

ApJ

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“…Another receptor that interacts with zinc is the zinc-specific receptor/G protein-linked receptor 39 (mZnR/GPR39) [163][164][165]. This receptor is expressed in cerebral areas such as cortex, amygdala or hippocampus [166], and, upon its activation by zinc, it triggers an increase in Ca+2 release and consequently the activation of a series of intracellular signaling pathways [167].…”

Section: Zinc Signalingmentioning

confidence: 99%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

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Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide. However, despite the continuous development of antiepileptic drugs, over 30% patients with epilepsy progress to drug-resistant epilepsy. For this reason, it is a high priority objective in preclinical research to find novel therapeutic targets and to develop effective drugs that prevent or reverse the molecular mechanisms underlying epilepsy progression. Among these potential therapeutic targets, we highlight currently available information involving signaling pathways (Wnt/β-catenin, Mammalian Target of Rapamycin (mTOR) signaling and zinc signaling), enzymes (carbonic anhydrase), proteins (erythropoietin, copine 6 and complement system), channels (Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy. Although some research with these specific targets has been done in relation with epilepsy, they have not been fully explored as potential therapeutic targets that could help address the unsolved issue of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.

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“…10 To date, studies have found that PKIB has the ability to enhance the constitutive activity of the G-protein-coupled zinc receptor GPR39 and may play important roles in vascular endothelial cells. 11,12 Furthermore, there are a few studies about the functions of PKIB in the tumor progression process. In breast cancers, PKIB expression is strongly correlated with the triplenegative breast cancer subtype, and overexpression of PKIB promotes tumor aggressiveness in prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells

Dou

Zhang

Cheng

et al. 2016

Exp Biol Med (Maywood)

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Lung cancer is one of the most common malignancies in the world, and non-small cell lung cancer (NSCLC) is a major subtype of lung cancer. Overgrowth of tumor cells usually results from the intensive proliferation of cancer cells, but the mechanisms by which the proliferation of cancer cells are promoted are currently unclear. Thus, it is necessary to determine the vital factors involved in regulating the growth of NSCLC. The MTT assay, BrdU assay, western blots, and migration and invasion assays were used in our study. Here, we found that PKIB (cAMP-dependent protein kinase inhibitor-b), a novel molecular target, was up-regulated in NSCLC tissues compared with the normal tissues adjacent to the tumors. Moreover, overexpression of PKIB promoted cell proliferation and potentiated the invasion and migration in A549 cells, whereas knocking down PKIB gene expression inhibited the proliferation and attenuated the invasive behavior and metastasis in H1299 cells. However, all of these effects of PKIB on cell proliferation and metastasis were reduced by inhibiting the PI3K/Akt pathway. Our results indicate that PKIB promotes cell proliferation and tumorigenesis by activating the PI3K/Akt pathway in NSCLC, implying that this is an important underlying mechanism that affects the progression of NSCLC.

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Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

Cited by 17 publications

References 35 publications

Clustered Cepheid Variables 90 Kiloparsecs From the Galactic Center

Clustered Cepheid Variables 90 Kiloparsecs From the Galactic Center

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

PKIB promotes cell proliferation and the invasion-metastasis cascade through the PI3K/Akt pathway in NSCLC cells

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