Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: Quantitative immunohistochemistry in tissue microarrays

Giusiano, Sophie; Cochet, Claude; Filhol, Odile; Duchemin-Pelletier, Eve; Secq, Véronique; Bonnier, Pascal; Carcopino, Xavier; Boubli, L.; Birnbaum, Daniel; García, Stéphane; Iovanna, Juan; Charpin, Colette

doi:10.1016/j.ejca.2010.11.028

Cited by 60 publications

(46 citation statements)

References 31 publications

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“…These findings support that CK2α plays an important role not only as a cancer driver but also as a metastatic indicator in thyroid cancers. Consistent with these findings it has been recently reported that CK2α over-expression correlated with metastatic risk in breast carcinomas (Giusiano et al, 2011).…”

Section: Discussionsupporting

confidence: 80%

Elevated Expression of Nuclear Protein Kinase CK2α as a Poor Prognosis Indicator in Lymph Node Cancerous Metastases of Human Thyroid Cancers

Guo¹,

Liu²,

Qi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Aim: To investigate the expression of protein kinase CK2α (CK2α) in human thyroid disease and its relationship with thyroid cancer metastasis. Materials and Methods: Using immunohistochemistry we measured the expression of CK2α in 76 benign and malignant human thyroid cancer tissues, including 10 pairs of papillary carcinoma tissues with or without lymph node cancerous metastasis and similarly 10 pairs of lymph nodes. Results: The expression of CK2α was found to be higher in thyroid carcinoma cases (papillary carcinoma, follicular carcinoma, anaplastic carcinoma and medullary carcinoma) than in ones such as chronic lymphocytic thyroiditis, nodular goiter and adenoma. These findings were also confirmed by RT-PCR and Western blotting. More strikingly, elevated expression of CK2α in thyroid papillary carcinoma tissues was not only significantly associated with lymph node cancerous metastasis and clinical stage of thyroid cancers; but also correlated with epithelial-mesenchymal transition (EMT) and high tenascin C (TNC) expression. In addition, EMT and high TNC expression in thyroid carcinoma tissues was significantly associated with lymph node cancerous metastasis. Conclusions: Elevated expression of nuclear CK2α is a poor prognosis indicator in lymph node cancerous metastasis of human thyroid cancers.

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Section: Discussionsupporting

confidence: 80%

Elevated Expression of Nuclear Protein Kinase CK2α as a Poor Prognosis Indicator in Lymph Node Cancerous Metastases of Human Thyroid Cancers

Guo¹,

Liu²,

Qi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Furthermore there is increasing evidence that CK2 can be responsible of tumor progression and drug resistance (63)(64)(65)(66)(67). In this study we showed that Notch ICD is a target of CK2 and, furthermore, that this phosphorylation regulates Notch activity.…”

Section: Discussionmentioning

confidence: 53%

Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

Ranganathan¹,

Carpió²,

Kaplan³

et al. 2011

Journal of Biological Chemistry

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“…Overexpression of CK2α has been shown to correlate with metastatic risk in breast carcinomas (46), poor prognosis in human colorectal carcinoma (47), and acute myeloid leukemia (48). However, in contrast to the reported observations with respect to CK2α no detailed information exists for the isozyme CK2α'.…”

Section: Discussioncontrasting

confidence: 46%

Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors

2011

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Abstract. Protein kinase CK2 is involved in several cellular processes and has lately also been linked to the DNA damage response through phosphorylations and interactions. Herein, we have analysed two sets of mouse cell lines, one pair, which is proficient and deficient in ATM and the other set expressing or lacking a functional catalytic subunit of the DNA dependent protein kinase (DNA-PKcs). Both kinases are implicated in the downstream phosphorylation of the signaling molecules such as BID and AKT1 in response to DNA damage. BID and AKT1 are also targets of CK2, hence the four cell lines were treated with the three established CK2 inhibitors DMAT, TBB and resorufin in the absence and presence of the radiomimetic drug neocarzinostatin, which induces DNA double-strand breaks. We show that there are differences with respect to the effect of the CK2 inhibitors on the phosphorylation of AKT1 at S473 and its downstream target GSK3β as well as between the two sets of cell lines. However, no such change was seen with BID phosphorylation. The most notably difference was the higher expression of CK2α' and CK2β in DNA-PKcs defective cells compared to the DNA-PKcs proficient cells.

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Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: Quantitative immunohistochemistry in tissue microarrays

Cited by 60 publications

References 31 publications

Elevated Expression of Nuclear Protein Kinase CK2α as a Poor Prognosis Indicator in Lymph Node Cancerous Metastases of Human Thyroid Cancers

Elevated Expression of Nuclear Protein Kinase CK2α as a Poor Prognosis Indicator in Lymph Node Cancerous Metastases of Human Thyroid Cancers

Hierarchical Phosphorylation within the Ankyrin Repeat Domain Defines a Phosphoregulatory Loop That Regulates Notch Transcriptional Activity

Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors

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