Protein kinase C (PKC) involved in enhancement of α1-adrenoceptor-mediated responses of the main pulmonary artery in rats with diabetes mellitus

Kizub, Igor V.; Kharchenko, O.; Kostiuk, Oleksandra; Остапченко, Л. И.; Soloviev, Anatoly I.

doi:10.15421/021745

Cited by 3 publications

(3 citation statements)

References 59 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The primary cause of the pathogenesis of coronary heart disease and atherosclerotic vascular damage is a deficiency of NO in the vascular endothelium and myocardium [ 23 ]. There are several factors causing endothelial NO deficiency: a decrease in eNOS activity [ 24 ], destruction or capture of NO by free radicals, and/or a weakening of the effect of NO on smooth muscle [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Features of Metabolic Support of Physical Performance in Highly Trained Cross-Country Skiers of Different Qualifications during Physical Activity at Maximum Load

Паршукова

Варламова

Потолицына

et al. 2021

Cells

View full text Add to dashboard Cite

The purpose of our study was to identify the features of metabolic regulation in highly trained cross-country skiers of different qualifications at different stages of the maximum load test. We examined 124 highly trained cross-country skiers (male, ages 17–24). The group consisted of two subgroups based on their competition performance: 61 nonelite athletes (Group I) and 63 elite athletes (group II), who were current members of the national team of the Komi Republic and Russia. The bicycle ergometer test was performed by using the OxyconPro system (Erich Jaeger, Hoechberg, Germany). All the examined athletes performed the exercise test on a cycle ergometer “until exhaustion”. The results of our research indicate that the studied groups of athletes with high, but different levels of sports qualifications are a convenient model for studying the molecular mechanisms of adaptation to physical loads of maximum intensity. Athletes of higher qualifications reveal additional adaptive mechanisms of metabolic regulation, which is manifested in the independence of serum lactate indicators under conditions of submaximal and maximum power from maximal oxygen uptake, and they have an NO-dependent mechanism for regulating lactate levels during aerobic exercise, including work at the anaerobic threshold.

show abstract

Section: Discussionmentioning

confidence: 99%

Features of Metabolic Support of Physical Performance in Highly Trained Cross-Country Skiers of Different Qualifications during Physical Activity at Maximum Load

Паршукова

Варламова

Потолицына

et al. 2021

Cells

View full text Add to dashboard Cite

show abstract

“…In particular, in most clinical studies ( 21 – 23 ), in patients with stage II hypertension (HT), a decrease in NO x levels was detected, which is quite common in the context of endothelial dysfunction. Deficiency of endothelial NO can be caused by several factors: a decrease in eNOS activity ( 21 ), destruction or capture of NO by free radicals, and/or a weakening of the effect of NO on smooth muscle ( 22 ). Reduced vasodilator function of the endothelium is an important link in the pathogenesis of HT.…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Production in Professional Skiers During Physical Activity at Maximum Load

Паршукова

Варламова

Bojko

2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

The purpose of this study is to assess the production of nitric oxide in professional cross-country skiers with normotensive and hypertensive responses to physical activity at maximum load. The observation group included professional cross-country skiers (22.2 ± 7.1 years, = 107) who were current members of the national team of the Komi Republic. All the examined athletes performed the exercise test on a cycle ergometer “until exhaustion.” The following parameters were determined for each participant while they were sitting at rest, while at their anaerobic threshold level, during peak load, and during the recovery period (5th min): systolic blood pressure, diastolic blood pressure, heart rate, and the level of stable nitric oxide metabolites (nitrites, nitrates) in capillary blood samples. According to the blood pressure results, the cross-country skiers were divided into two groups. Group I included athletes with a normotensive response to stress. Group II was composed of individuals with a hypertensive response to stress. During the performance of the test “until exhaustion,” a significant (p < 0.05) increase in the amount of stable metabolites of nitric oxide was observed in the group of athletes with a normotensive response to the load compared with the group with a hypertensive response to the load. In athletes with a normotensive reaction to the load during exercise at maximum load and in the early recovery period, nitrate was prioritized in the regulation of vascular tone. The exercise test on a cycle ergometer “until exhaustion,” combined with the assessment of the levels of stable nitric oxide metabolites in plasma, can be considered a test for the early diagnosis of endothelial dysfunction in professional athletes.

show abstract

“…Показано, що за умов ЦД у легеневій артерії посилюється активність протеїнкінази С в ендотелії, що призводить до зростання скоротиливості основних легеневих артерій [61]. Але загалом її значення в змінах регуляції судинного тонусу легеневих артерій під впливом ЦД вивчене недостатньо.…”

Section: активація протеїнкінази сunclassified

Diabetes Mellitus and Pulmonary Circulation (Part 1)

Dobrelia¹,

Khromov²

2019

Fiziol Zh

View full text Add to dashboard Cite

Останнім часом все більше уваги приділяють впливу цукрового діабету на легеневий кровообіг, адже при ньому спостерігається значне зростання захворювань легень та можливий зв'язок діабету з легеневою артеріальною гіпертензією. Хронічна гіперглікемія запускає каскад патологічних реакцій, основу яких складає окисний стрес, який виникає через збільшення донорів вільних електронів, що посилює потік електронів через мітохондріальний електронно-транспортний ланцюг. Оскільки численні дослідження підтверджують зростання концентрації активних форм кисню в легеневих артеріях за умов цукрового діабету цей пошкоджуючий механізм є універсальним для обох кіл кровообігу. Наслідки гіперглікемії, а саме окисний стрес, активізація поліолового та гексозамінового шляхів метаболізму глюкози, активація протеїнкінази С й посиленого утворення кінцевих продуктів глікування підвищують констрикторну здатність судин великого кола кровообігу, але вплив цих факторів на судини малого кола кровообігу вивчений недостатньо. У легенях виявлено експресію рецепторів інсуліну та глюкозних транспортерів, але дані щодо їх локалізації в судинній стінці легеневих артерій, щільності та змін на рецепторному чи пострецепторному рівнях за розвитку інсулінорезистентності практично відсутні. Ключові слова: цукровий діабет; легенева артерія; гіперглікемія.

show abstract

Protein kinase C (PKC) involved in enhancement of α1-adrenoceptor-mediated responses of the main pulmonary artery in rats with diabetes mellitus

Cited by 3 publications

References 59 publications

Features of Metabolic Support of Physical Performance in Highly Trained Cross-Country Skiers of Different Qualifications during Physical Activity at Maximum Load

Features of Metabolic Support of Physical Performance in Highly Trained Cross-Country Skiers of Different Qualifications during Physical Activity at Maximum Load

Nitric Oxide Production in Professional Skiers During Physical Activity at Maximum Load

Diabetes Mellitus and Pulmonary Circulation (Part 1)

Contact Info

Product

Resources

About