Protein kinase C-dependent inhibition of K+ currents in noradrenaline-induced depolarization of smooth muscle of guinea-pig vas deferens

Regulation of corticotropin‐releasing hormone neuronal network activity by noradrenergic stress signals

“…Randle et al (1986) performed intracellular electrophysiological recordings from magnocellular neurons and showed that noradrenaline or α 1 -adrenoceptor agonists depolarised these neurons by reducing a K + leak current. This reduction in K + conductance by α 1 -adrenoceptor activation is not only seen in magnocellular neurons but has also been demonstrated in several other cell types (Kamimura et al, 2000;Larkman & Kelly, 1992;McCormick, 1992;Pan et al, 1994). While not specifically tested in this current study, this mechanism fits with our current data.…”