Cell Membranes 1987
DOI: 10.1007/978-1-4613-1915-3_6
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Protein Kinase C and its Role in Cell Growth

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Cited by 35 publications
(12 citation statements)
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“…In contrast to TPA, these agents result in transient and substoichiometric phosphorylation of S12 in pp60csrc. This difference in kinetics can be explained by the transient, rather than prolonged, activation of protein kinase C by these agents and presumably by the restriction of protein kinase C activated by diacylglycerols to the plasma membrane (for a review, see reference 66), where not all pp60csrc molecules are located (55).…”
Section: Resultsmentioning
confidence: 99%
“…In contrast to TPA, these agents result in transient and substoichiometric phosphorylation of S12 in pp60csrc. This difference in kinetics can be explained by the transient, rather than prolonged, activation of protein kinase C by these agents and presumably by the restriction of protein kinase C activated by diacylglycerols to the plasma membrane (for a review, see reference 66), where not all pp60csrc molecules are located (55).…”
Section: Resultsmentioning
confidence: 99%
“…A detailed computer analysis of smaller fragments in the NPAT product showed similarities with a large number of known protein motifs, enabling us to identify the region with possible functional importance. Notable were five consensus sequences for phosphorylation by CDK4/E2F and CDK6/E2F complexes (Ser/Thrpro-X-Lys/Arg) (Nigg 1993a), 24 protein kinase C phosphorylation target sites (Ser/Thr-X-Lys/Arg) (Kishimoto et al 1985;Woodgett et al 1986), and three cAMP/cGMP-dependent protein kinase phosphorylation target sequences (Lys/Arg-Lys/ Arg-X-Ser/Thr) (Feramisco et al 1980) (Fig. 4).…”
Section: Predicted Amino Acid Sequence Of Npatmentioning
confidence: 99%
“…Protein kinase C (PKC), as first described by Nishizuka and colleagues, has been implicated in the control of many cellular processes (reviewed in [1,2]). It is now clear that the general properties used to define the enzyme are shared by a group of related proteins first identified through structural analysis [3][4][5][6][7][8][9].…”
Section: Introductionmentioning
confidence: 99%