Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties

Efficacy and Safety of Phyllanthus Niruri in Non-alcoholic Steatohepatitis Treatment: Pilot Study from Malaysia

“…Although there have been numerous studies into the antiinflammatory, antioxidant and hepatoprotective properties of Phyllanthus niruri, [9,18] the current study, to the best knowledge of the authors, is the first to investigate its value specifically in NASH treatment. Besides, different from the other preclinical studies which were primarily limited by the variations in methods, [9] this is the first randomized controlled trial designed to determine the effectiveness and safety of a commercially available product containing a standardized content of Phyllanthus niruri extract.…”

“…Besides, different from the other preclinical studies which were primarily limited by the variations in methods, [9] this is the first randomized controlled trial designed to determine the effectiveness and safety of a commercially available product containing a standardized content of Phyllanthus niruri extract. The strength of the current study also lies in the 48-week followup period, which is consistent with the recommendation of the American Association for Study of Liver Diseases on the duration for NASH trials.…”

“…[5][6][7][8] Phyllanthus niruri, a herb extensively used in traditional Malay, Chinese and Ayurvedic medicine, is a potential therapeutic agent for a wide range of liver diseases, as laboratory studies have confirmed its antiviral, anti-inflammatory, antioxidant and hepatoprotective properties. [9][10][11][12][13] However, it has never been tested in patients, particularly those with NASH. Hence, this pilot study was designed to confirm the efficacy and safety of a commercially available product, HEPAR-P ® (Nova Laboratories), which was standardized to contain 250 mg of Phyllanthus niruri extract EPN 797 (4% of corilagin and 18% of phyllanthus flavonoids) per capsule.…”

Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review

“…Similar result was found when another very common herb, Phyllanthus niruri, known to have hepatoprotective property, was searched for its active constituent for antioxidant action. A 35 kDa protein has been isolated from that herb having similar property with the protein isolated from the leaves of C. indicus [67][68][69][70][71][72][73][74]. However, the two protein molecules do not have any primary structural similarity although functionally they share many common activities.…”

In Vivo Carbon Tetrachloride-Induced Hepatoprotective and in Vitro Cytotoxic Activities of Garcinia Hombroniana (Seashore Mangosteen)

“…For example, some plants such as Picrorhiza kurroa (Schuppan et al, 1999) and Phyllanthus niruri (Bhattacharjee & Sil, 2007) have been traditionally used for the ailments of liver complications. Silymarin and silybin, the most effective hepatoprotective and clinically used agents in hepatic diseases were isolated from Silybum marianum (family Asteraceae) (Fernandes et al, 1995).…”