Protein Immobilization onto Silicon Nanowires via Electrografting of Hexynoic Acid

Surface modification of semiconducting silicon nanowires for biosensing applications

“…The formation of alkane and alkene organic layers via electrochemical grafting has been demonstrated on H-terminated SiNW. 113 Scheibal et al used cathodic electrografting of hexynoic acid to H-SiNW surfaces (dense arrays of silicon nanowires approximately 50-100 nm in diameter and 10 μ m in length). Then, using NHS/EDC strategy, bovine serum albumin (BSA) was immobilized.…”

Electrochemical Coating of Medical Implants

“…Acrylates, methacrylates, thiols, amines 64,125 and triple bond 126 have been successfully electrografted on various conducting surfaces. In this method, the expected thickness of the organic film ranges between a monolayer to hundred of nanometers if the organic molecule can be polymerized under cathodic conditions 62 and the film does not block electron transfer.…”

Electrografting of Organic Monolayers on Planar and Nanowire Silicon Substrates

“…Protein sensing via electrochemical impedance spectroscopy (EIS) Bovine Serum Albumin (BSA) protein immobilization over hexynoic acid terminated silicon nanowires are previously demonstrated (4). Electrochemical impedance spectroscopy (EIS) is used to determine the presence of the protein upon the functionalized silicon surface.…”