Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice

Parthsarathy, Vadivel; McLaughlin, Chris M.; Sharkey, Shaun J; Harnedy‐Rothwell, Pádraigín A.; Lafferty, Ryan A.; Allsopp, Philip J.; McSorley, Emeir M.; Fitzgerald, Richard J.; O’Harte, Finbarr

doi:10.31665/jfb.2021.16292

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Atlantic salmon (Salmo salar) processing byproducts, often considered secondary raw materials in the production of value-added human-consumable products, are frequently identified as potent sources of glucoregulatory peptides. In one pre-clinical study on knockout mice, a fish protein hydrolysate was deemed to exert a capacity for beneficial glucoregulatory effects, with a potency on par with Metformin, a drug used in the management of type 2 diabetes [69]. A crucial future consideration is the bioavailability of such interventions, should such interventions be employed to address metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro

Bjerknes,

Wubshet,

Rønning

et al. 2024

Marine Drugs

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Metabolic disorders are increasingly prevalent conditions that manifest pathophysiologically along a continuum. Among reported metabolic risk factors, elevated fasting serum glucose (FSG) levels have shown the most substantial increase in risk exposure. Ultimately leading to insulin resistance (IR), this condition is associated with notable deteriorations in the prognostic outlook for major diseases, including neurodegenerative diseases, cancer risk, and mortality related to cardiovascular disease. Tackling metabolic dysfunction, with a focus on prevention, is a critically important aspect for human health. In this study, an investigation into the potential antidiabetic properties of a salmon protein hydrolysate (SPH) was conducted, focusing on its potential dipeptidyl peptidase-IV (DPP-IV) inhibition and direct glucose uptake in vitro. Characterization of the SPH utilized a bioassay-guided fractionation approach to identify potent glucoregulatory peptide fractions. Low-molecular-weight (MW) fractions prepared by membrane filtration (MWCO = 3 kDa) showed significant DPP-IV inhibition (IC50 = 1.01 ± 0.12 mg/mL) and glucose uptake in vitro (p ≤ 0.0001 at 1 mg/mL). Further fractionation of the lowest MW fractions (<3 kDa) derived from the permeate resulted in three peptide subfractions. The subfraction with the lowest molecular weight demonstrated the most significant glucose uptake activity (p ≤ 0.0001), maintaining its potency even at a dilution of 1:500 (p ≤ 0.01).

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Section: Discussionmentioning

confidence: 99%

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro

Bjerknes,

Wubshet,

Rønning

et al. 2024

Marine Drugs

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Salmon processing discards: a potential source of bioactive peptides – a review

Ramakrishnan,

Hossain,

Dave

et al. 2024

Food Prod Process and Nutr

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Salmon aquaculture generates 80% of the total revenue of finfish aquaculture across Canada. Salmon farming is carried out in a multilevel process, and at least 60% of the total production is considered as by-products, including skin, head, viscera, trimmings, frames, bones, and roes. These by-products are an excellent source of protein, which can be converted to protein hydrolysates through enzymatic hydrolysis and non-enzymatic processes such as chemical hydrolysis (acid and alkaline) in order to utilize them into value-added products. Several studies have reported that peptides from salmon protein hydrolysates possess bioactivities, including antihypertensive, antioxidant, anticancer, antimicrobial, antidiabetic, anti-allergic, and cholesterol-lowering effects. Incorporating in silico computational methods is gaining more attention to identify potential peptides from source proteins. The in silico methods can be used to predict the properties of the peptides and thereby predetermine the processing, isolation, and purification steps that can be used for the peptides of interest. Therefore, it is essential to implement robust, standardized, and cost-effective processing techniques that can easily be transferrable and scale up for industrial applications in view of circular economy and upcycling concept. This contribution summarizes the latest research information on Atlantic salmon, production statistics, growth lifecycle, processing, protein production techniques, nutritional and functional properties, peptide production and purification processes, as well as potential health benefits as a nutraceutical product. Graphical Abstract

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Protein hydrolysates from boarfish (Capros aper) and Atlantic salmon (Salmo salar) skin gelatin improve metabolic control in genetically obese diabetic (ob/ob) mice

Cited by 2 publications

References 41 publications

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro

Salmon processing discards: a potential source of bioactive peptides – a review

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