Protein expression status of p53 and epidermal growth factor receptor in thymoma

Abstract

Abstract. Evaluating the state of malignancy of thymoma is a challenge due to the discrepancies between pathological classifications and clinical stage criteria. Therefore, the identification of markers contributing to the assessment of the stage of malignancy of thymoma would be useful. This study aimed to evaluate the prevalence of p53 and epidermal growth factor receptor (EGFR) in thymoma, demonstrate the clinical significance and assess the potential of specifictargeted therapy. A total of 16 thymic hyperplasia patients and 43 thymoma patients were included in the study. Samples were tested for the expression of p53 and EGFR using immunohistochemistry. In the multivariate analysis, the thymoma cases were followed up to analyze the relationship between survival rates and a number of potential factors, such as p53 and EGFR. There were 21 completely resected stage Ⅱ cases which were evaluated for relapse-free time. the p53 groups following a survey conducted to assess relapse time. Therefore, the application of EGFR-targeting agents is warranted in invasive thymoma, whereas the targeting of p53 has yet to be elucidated.

Diagnostic Roles of Immunohistochemistry in Thymic Tumors: Differentiation between Thymic Carcinoma and Thymoma

“…Data associated with various IHC expressions of TC and TM were extracted from each of the eligible studies [ 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Two independent authors extracted all of the data.…”

“…In addition, Nakagawa et al reported that the combination of CD117 and CD5 was useful for differentiating between thymic and lung squamous cell carcinoma [ 8 ]. Insulin-like growth factor-1 receptor (IGF-1R) was proposed as a potential therapeutic target for TET and is more frequently expressed in TC than in TM [ 9 , 10 , 11 ].…”

Bone morphogenetic protein-7 expression reflects the high proliferative ability and aggressiveness of thymic epithelial tumors

“…Bone morphogenetic protein-7 expression reflects the high proliferative ability and aggressiveness of thymic epithelial tumors their biological behaviors, the classification of thymic epithelial tumors remains challenging. Although several factors, such as podoplanin, p53, Ki-67, and GLUT-1, have been reported to be associated with the individual biological behavior of thymic epithelial tumors (3)(4)(5)(6)(7), more unique markers which reflect the biology of thymic epithelial tumors are required. In order to detect the expression of molecules that are important for the progression of thymic epithelial tumors, we compared gene expression profiles using microarray analysis between the normal thymus and type B2 thymoma in clinical specimens obtained in our department.…”