Protein Engineering Using Unnatural Amino Acids

Construction of carbazole-based unnatural amino acid scaffolds via Pd(ii)-catalyzed C(sp3)–H functionalization

“…In general, the synthesis and biological evaluation of unnatural amino acid derivatives (non-proteinogenic amino acid derivatives) are a prominent topic in chemical biology and drug discovery research. 11 Unnatural amino acids including d -amino acids are used as building blocks in organic synthesis for assembling various bio-active synthetic molecules. 11 Unnatural amino acid derivatives are important tools when incorporated into peptide molecules and can be used as molecular probes to understand the function of biological systems.…”

“…11 Unnatural amino acids including d -amino acids are used as building blocks in organic synthesis for assembling various bio-active synthetic molecules. 11 Unnatural amino acid derivatives are important tools when incorporated into peptide molecules and can be used as molecular probes to understand the function of biological systems. 11 Given the importance of unnatural amino acids in research fields including organic synthesis, medicinal chemistry and chemical biology, there has been a persistent effort toward synthesizing novel unnatural amino acid derivatives.…”

“…11 Given the importance of unnatural amino acids in research fields including organic synthesis, medicinal chemistry and chemical biology, there has been a persistent effort toward synthesizing novel unnatural amino acid derivatives. 4–6,11…”