Protein-energy malnutrition in patients with ischemic and nonischemicdilated cardiomyopathy and congestive heart failure

Schwengel, Robert H.; Gottlieb, Stephen S.; Fisher, Michael L.

doi:10.1016/0002-9149(94)90825-7

Cited by 28 publications

(16 citation statements)

References 6 publications

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“…Another factor that could favour ketogenesis in CHF is an imbalance between the supply and need of calories. Malnutrition is not rare and is thought to reflect reductions in food intake and absorption as well as increased basal metabolism and possibly cellular hypoxia [2,3,4,[20][21][22]. Increased secretion of tumour necrosis factor may also contribute [23,24].…”

Section: Discussionmentioning

confidence: 99%

Heart failure ketosis

Lommi¹,

Koskinen²,

Näveri³

et al. 1997

Journal of Internal Medicine

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Abstract. Lommi J, Koskinen P, Näveri M, Härkönen M, Kupari M (Helsinki University Central Hospital, Helsinki, Finland). Heart failure ketosis. J Intern Med 1997; 242: 231-8.Objective. To assess whether blood ketone bodies are increased in congestive heart failure (CHF). Methods. Thirteen patients with CHF and 11 cardiac patients without CHF took part in the study. Blood acetoacetate and b-hydroxybutyrate levels and the pertinent metabolic and hormonal milieu were measured during 20 h fast and after 2 h glucose infusion. Results. The averaged blood ketone body and free fatty acid levels were significantly higher during the fast and also remained higher after glucose infusion in patients with CHF than in the control group. The areas under ketone body concentration time curve over the last 8 h of the fast were 3522 Ϯ 662 mol L Ϫ1 h Ϫ1 (SE) and 1789 Ϯ 192 mol L Ϫ1 h Ϫ1 in patients with and without CHF, respectively (P = 0.022). Circulating noradrenaline and growth hormone were higher but glucagon lower in patients with CHF than in the controls (P Ͻ 0.05 for all differences) whereas the glucose and insulin concentrations were comparable in the study groups. At the time of peak ketonaemia, the glucagon-to-insulin ratio was lower in patients with CHF than in patients without CHF (P ϭ 0.04). Conclusions. These data suggest that severe CHF is a ketosis-prone state. Augmented supply of free fatty acids for ketogenesis due to increased stress hormone-related lipolysis is one likely mechanism.

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Section: Discussionmentioning

confidence: 99%

Heart failure ketosis

Lommi¹,

Koskinen²,

Näveri³

et al. 1997

Journal of Internal Medicine

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“…There is accumulating evidence that malnutrition is common and affects disease progression in patients with chronic HF [1][2][3]. Importantly, cardiac cachexia, an advanced manifestation of nutritional impairment, has been recognized as an important factor in deteriorating HF [22].…”

Section: Impact Of Nutritional Screening In Patients With Ahfs In Emementioning

confidence: 99%

“…Malnutrition is often observed in patients with heart failure (HF) and associated with adverse clinical outcomes [1][2][3]. Several studies have demonstrated the significance of malnutrition in chronic HF because of its association with long-term clinical outcomes [4].…”

Section: Introductionmentioning

confidence: 99%

Risk stratification based on nutritional screening on admission: Three-year clinical outcomes in hospitalized patients with acute heart failure syndrome

Fujino

Takahama

Hamasaki

et al. 2016

Journal of Cardiology

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“…It has been shown that omega-3 PUFAs also play a beneficial role in patients with advanced HF. It is well known that patients with advanced HF experience weight loss and even frank cachexia [33]. The prognosis in HF is significantly worsened by the presence of cachexia.…”

Section: Evidence For Omega-3 Polyunsaturated Fatty Acids In Heart Famentioning

confidence: 99%

Should We Start Prescribing Omega-3 Polyunsaturated Fatty Acids in Chronic Heart Failure?

Jarreau

Lee

Lavie

et al. 2011

Curr Heart Fail Rep

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Chronic heart failure (HF) represents a significant health care burden. Over the past few decades, there have been considerable data supporting the benefits of omega-3 polyunsaturated fatty acids (PUFAs) on overall cardiovascular health. Reasons for the potential benefits of omega-3 PUFAs are multifactorial and not completely understood. It is likely that the culmination of multiple effects collectively help to prevent the development and slow the progression of chronic HF. A number of key epidemiologic and randomized trials have provided the basis of evidence in support of omega-3 PUFA supplementation in HF. This article reviews the benefits of omega-3 PUFAs and discusses the implications of recent trials. While the benefits seen in patients with chronic HF are modest at best, we believe the balance of evidence still favors the continuation of omega-3 PUFA supplementation in patients with chronic HF.

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Protein-energy malnutrition in patients with ischemic and nonischemicdilated cardiomyopathy and congestive heart failure

Cited by 28 publications

References 6 publications

Heart failure ketosis

Heart failure ketosis

Risk stratification based on nutritional screening on admission: Three-year clinical outcomes in hospitalized patients with acute heart failure syndrome

Should We Start Prescribing Omega-3 Polyunsaturated Fatty Acids in Chronic Heart Failure?

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