Abstract:Oxidative crosslinking of protein thiols via disulfide bonds, promoted by non‐radical peroxides, offers alternatives to traditional, oxygen radical‐centered, perspectives with which to consider the impacts of oxidative stress on brain functions. Protein disulfides, involving the bridging of closely‐spaced (vicinal) thiol pairs, as well as protein‐glutathione mixed disulfides occur readily in cells exposed to hydrogen peroxide but the scope, pathways, and relationships to health and disease of protein thiol oxi… Show more
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