2023
DOI: 10.1186/s13046-023-02640-1
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Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy

Abstract: Introduction Increasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in the endoplasmic reticulum stress (ERS) response. However, the role of PDIA4 in regulating glioblastoma (GBM)-specific pro-angiogenesis is still unknown. Methods The expression and prognostic role of PDIA4 were analyzed using a bioinformatics approach and were validated in 32 clinical samples and follow-up data. RNA-sequencing was used to sear… Show more

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Cited by 7 publications
(7 citation statements)
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“…Protein disulfide isomerase A4 (PDIA4) is a member of the multi-protein chaperone complex, performing diverse functions by interacting with its specific substrates [ 23 ]. A growing body of evidence demonstrated that aberrant PDIA4 expression level and its potential mechanisms participate in the development of numerous types of cancer, including GBM [ 24 ]. PDIA4 is a key promotor of GBM.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Protein disulfide isomerase A4 (PDIA4) is a member of the multi-protein chaperone complex, performing diverse functions by interacting with its specific substrates [ 23 ]. A growing body of evidence demonstrated that aberrant PDIA4 expression level and its potential mechanisms participate in the development of numerous types of cancer, including GBM [ 24 ]. PDIA4 is a key promotor of GBM.…”
Section: Discussionmentioning
confidence: 99%
“…The upregulation of PDIA4 in GBM was particularly pronounced when compared to normal tissues. A growing body of evidence underscored the pivotal role of PDIA4 in the endoplasmic reticulum (ER) stress response [ 24 ]. In tumor microenvironments, various metabolic abnormalities collaborate to disrupt ER homeostasis in malignant and stromal cells, as well as immunocytes.…”
Section: Discussionmentioning
confidence: 99%
“…The procedure of tumor sample IHC staining was performed, and the quantification was calculated according to a previous publication strictly 22 .…”
Section: Methodsmentioning
confidence: 99%
“…A recent study reported that the expression level of VEGF is an independent risk factor for glioma prognosis ( 33 ). Studies have found that GBM cells express and secrete VEGFA protein, which was regulated by protein disulfide isomerase A4 in GBM cells ( 34 , 35 ). Another study of GBM has shown that VEGFA was dramatically overexpressed while no significant change of VEGFB expression was detected in GBM patients ( 36 ).…”
Section: Vegfmentioning
confidence: 99%