Protein corona variation in nanoparticles revisited: A dynamic grouping strategy

Rezaei, Ghassem; Daghighi, Seyed Mojtaba; Haririan, Ismaeil; Yousefi, Iman; Raoufi, Mohammad; Rezaee, Farhad; Dinarvand, Rassoul

doi:10.1016/j.colsurfb.2019.04.003

Cited by 14 publications

(9 citation statements)

References 200 publications

(283 reference statements)

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“…Unfortunately, there are often no agreements on how to perform uptake studies in a standardized way. Recently, this problem has gotten much attention in the nanomedicine field [166,167,180]. Within the nanosafety community, dedicated to the study of potential hazards of nanotechnologies, several efforts have been focused on the establishment of standardized procedures for nanomaterial handling and for cell interaction studies in order to ensure quality in nanosafety testing [181][182][183].…”

Section: Challenges In Studying Endocytosis Of Nano-sized Materials Imentioning

confidence: 99%

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

Francia¹,

Montizaan²,

Salvati³

2020

Beilstein J. Nanotechnol.

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Nano-sized materials have great potential as drug carriers for nanomedicine applications. Thanks to their size, they can exploit the cellular machinery to enter cells and be trafficked intracellularly, thus they can be used to overcome some of the cellular barriers to drug delivery. Nano-sized drug carriers of very different properties can be prepared, and their surface can be modified by the addition of targeting moieties to recognize specific cells. However, it is still difficult to understand how the material properties affect the subsequent interactions and outcomes at cellular level. As a consequence of this, designing targeted drugs remains a major challenge in drug delivery. Within this context, we discuss the current understanding of the initial steps in the interactions of nano-sized materials with cells in relation to nanomedicine applications. In particular, we focus on the difficult interplay between the initial adhesion of nano-sized materials to the cell surface, the potential recognition by cell receptors, and the subsequent mechanisms cells use to internalize them. The factors affecting these initial events are discussed. Then, we briefly describe the different pathways of endocytosis in cells and illustrate with some examples the challenges in understanding how nanomaterial properties, such as size, charge, and shape, affect the mechanisms cells use for their internalization. Technical difficulties in characterizing these mechanisms are presented. A better understanding of the first interactions of nano-sized materials with cells will help to design nanomedicines with improved targeting.

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Section: Challenges In Studying Endocytosis Of Nano-sized Materials Imentioning

confidence: 99%

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

Francia¹,

Montizaan²,

Salvati³

2020

Beilstein J. Nanotechnol.

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“…Thus, in vitro and in vivo are equally important to understand the interactions. Furthermore, many parameters from the system itself are still very hard to simulate 143 even if they influence the amount and the concentration of proteins in biological fluids. For example, in vitro analyses are usually performed in serum when the same in vivo experiments are performed in plasma.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, in vitro and in vivo are equally important to understand the interactions. Furthermore, many parameters from the system itself are still very hard to simulate 143 119,140 but compare it to a serum pooled from many animals. The concentrations, amounts and nature of the proteins may statistically differ and lead to significant altered results.…”

Section: Discussionmentioning

confidence: 99%

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

et al. 2021

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“…Furthermore, it has been reported that nanoparticles interact with various biological components in vivo , which are absorbed onto the nanoparticle-biological medium interface, commonly known as the protein corona. Formation of the protein corona layer changes nanoparticle surface characteristics drastically resulting in a major deviation in therapeutic efficacy ( Rezaei et al, 2019 ). In comparison, exosomes can inherently circumvent some of these limitations.…”

Section: Comparing Exosomes To Other Nano-pharmaceuticalsmentioning

confidence: 99%

Exosomes: Biological Pharmaceutical Nanovectors for Theranostics

Thomas

Kim

Pauletti

et al. 2022

Front. Bioeng. Biotechnol.

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Exosomes are natural cell-derived nanovesicles of endocytic origin that enable cellular crosstalk by transferring encapsulated molecular cargos across biological barriers, thereby holding significantly complex implications in the etiology and progression of diverse disease states. Consequently, the development of exosomes-based nano-theranostic strategies has received immense consideration for advancing therapeutic interventions and disease prognosis. Their favorable biopharmaceutical properties make exosomes a unique nanoparticulate carrier for pharmaceutical drug delivery. This review provides an update on the contemporary strategies utilizing exosomes for theranostic applications in nanomedicine. In addition, we provide a synopsis of exosomal features and insights into strategic modifications that control in vivo biodistribution. We further discuss their opportunities, merits and pitfalls for cell/tissue targeted drug delivery in personalized nanotherapy.

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Protein corona variation in nanoparticles revisited: A dynamic grouping strategy

Cited by 14 publications

References 200 publications

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

Exosomes: Biological Pharmaceutical Nanovectors for Theranostics

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