Abstract:Organisms, from algae to humans are known to mold complex, hierarchical hard tissues from minerals using biomolecular templates and additives. Molecular-level mechanistic understanding of how these biomolecules, particularly proteins, participate in the nucleation and growth of these inorganic crystals has been a longstanding goal. We design peptides with transformative abilities over calcite crystals using Rosetta. Based on the theory of how additives alter crystal nucleation and growth, we employ four modifi… Show more
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