Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation

Smutná, Marie; Beňová, Katarí­na; Dvořák, Petr; Nekvapil, Tomáš; Kopřiva, Vladimír; Máté, D.

doi:10.1016/j.rvsc.2012.09.002

Cited by 7 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For Bl41 and J3D cells treated with VER-155008, we observed a significant increase in apoptosis induction after PT irradiation in comparison to either inhibitor or radiation treatment alone (Fig3E). Ionizing radiation is known to damage proteins by oxidation due to reactive oxygen species (ROS) generation [27][28][29] , and protein oxidation in turn can trigger the unfolded protein response leading to reduced protein translation 30,31 . Increased overall protein oxidation was observed at 12hr post PT compared to X-ray or control cells (Fig4A), consistent with the observed reduced translation in response to particle radiation.…”

Section: Resultsmentioning

confidence: 99%

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Sertorio

Nowrouzi²,

Akbarpour³

et al. 2021

Radiotherapy and Oncology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Resultsmentioning

confidence: 99%

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Sertorio

Nowrouzi²,

Akbarpour³

et al. 2021

Radiotherapy and Oncology

View full text Add to dashboard Cite

show abstract

“…Repair processes for proteins modified by carbonylation have not been identified, and, instead, degradation is believed to be the primary mechanism for cellular regulation of proteome carbonylation (201). Increased levels of protein carbonyls have been noted after IR exposure (10 Gy) (310,317), and in addition, have been implicated in the pathophysiology of many human disease states, including chronic lung disease (357), neurodegenerative diseases (133), diabetes (2), and ischemiareperfusion injury [(84) and references therein].…”

Section: Protein Oxidationmentioning

confidence: 99%

Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

Reisz

Bansal²,

Qian³

et al. 2014

Antioxidants & Redox Signaling

606

447

View full text Add to dashboard Cite

show abstract

“…Other agents that lead to protein oxidation include reagents, such as xenobiotics, such as paraquat, CCl 4 , and acetaminophen, cigarette smoke, reduced transition metals, such as Fe 2+ or Cu + , γ-irradiation in the presence of O 2 , activated neutrophils, ultraviolet light, ozone, oxidoreductase enzymes, and by-products of lipid and free amino acid oxidation ( 21 , 25 ). For example, pigs exposed to whole body γ-irradiation showed a significant increase in protein carbonyls ( 27 ). As a consequence of the large variety of agents that cause protein oxidation and because all of the amino acyl side chains can become oxidatively modified, there are numerous different types of protein oxidative modification ( 22 ).…”

Section: Protein Oxidationmentioning

confidence: 99%

Oxidant/Antioxidant Balance in Animal Nutrition and Health: The Role of Protein Oxidation

2015

View full text Add to dashboard Cite

This review examines the role that oxidative stress (OS), and protein oxidation in particular, plays in nutrition, metabolism, and health of farm animals. The route by which redox homeostasis is involved in some important physiological functions and the implications of the impairment of oxidative status on animal health and diseases is also examined. Proteins have various and, at the same time, unique biological functions and their oxidation can result in structural changes and various functional modifications. Protein oxidation seems to be involved in pathological conditions, such as respiratory diseases and parasitic infection; however, some studies also suggest that protein oxidation plays a crucial role in the regulation of important physiological functions, such as reproduction, nutrition, metabolism, lactation, gut health, and neonatal physiology. As the characterization of the mechanisms by which OS may influence metabolism and health is attracting considerable scientific interest, the aim of this review is to present veterinary scientists and clinicians with various aspects of oxidative damage to proteins.

show abstract

Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation

Cited by 7 publications

References 17 publications

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

Oxidant/Antioxidant Balance in Animal Nutrition and Health: The Role of Protein Oxidation

Contact Info

Product

Resources

About