Protein carbonyl levels in the aqueous humour and serum of patients with pseudoexfoliation syndrome

Yağcı, Ramazan; Ersöz, İbrahim; Erdurmuş, Mesut; Gürel, Ahmet; Duman, Sunay

doi:10.1038/sj.eye.6702751

Cited by 24 publications

(8 citation statements)

References 28 publications

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“…The current study, which included 202 subjects with OAG, is the largest such study to assess the systemic redox status in glaucoma 15 17 18 19 20 21 22 23 24 25 26 27 28 29 . Yagci et al .…”

Section: Discussionmentioning

confidence: 99%

Association between systemic oxidative stress and visual field damage in open-angle glaucoma

Tanito

Kaidzu

Takai

et al. 2016

Sci Rep

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Local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage may be involved in the pathogenesis of glaucoma. We reported previously that a lower level of systemic antioxidative capacity is associated with IOP elevation in open-angle glaucoma (OAG). We assessed the correlation between the visual field sensitivity value, i.e., mean deviation (MD), and systemic levels of prooxidants and antioxidants by analyzing the blood biochemistry in 202 patients with glaucoma. Serum levels of lipid peroxides, ferric-reducing activity, and thiol antioxidant activity were measured using the diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and sulfhydryl (SH) tests, respectively, using a free-radical analyzer. Univariate and multivariate analyses suggested a positive correlation between MD and BAP (R = 0.005 and P = 0.0442 by a multiple regression model adjusted for seven demographic parameters), but no significant associations between the MD and the dROM (R = 0.002 and P = 0.8556) and SH tests (R = −0.001 and P = 0.8280). Use of more antiglaucoma medication and primary OAG rather than normal tension glaucoma also were associated significantly with worse visual field damage. This large and comprehensive assessment of the association between systemic redox status and visual field damage in OAG suggests that lower systemic antioxidant capacity measured by ferric-reducing activity is associated with more severe visual field damage in OAG that partly explained its roles in IOP elevation.

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Section: Discussionmentioning

confidence: 99%

Association between systemic oxidative stress and visual field damage in open-angle glaucoma

Tanito

Kaidzu

Takai

et al. 2016

Sci Rep

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“…Several previous studies have reported lower systemic levels of antioxidants or antioxidative stress capacity in glaucoma [ 15 , 18 , 20 , 21 , 23 , 28 ]. Other studies have tested simultaneously the status of systemic and local redox [ 16 , 17 , 22 , 24 ]. Yagci et al found increased protein carbonylation, which is a measure of protein oxidation, in aqueous and serum samples from EX compared with controls [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have tested simultaneously the status of systemic and local redox [ 16 , 17 , 22 , 24 ]. Yagci et al found increased protein carbonylation, which is a measure of protein oxidation, in aqueous and serum samples from EX compared with controls [ 16 ]. Koliakos et al identified significantly lower levels of antioxidative stress enzyme catalase activities in aqueous and serum samples from EX compared with controls [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Systemic Oxidative Stress and Intraocular Pressure Level

et al. 2015

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BackgroundThe involvement of local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage has been hypothesized in the pathogenesis of glaucoma. We reported previously that the level of systemic antioxidative capacity is lower in patients with open-angle glaucoma than controls without glaucoma. Here, we assessed the correlation between IOP and systemic levels of prooxidants and antioxidants by analyzing the blood biochemistry in patients with glaucoma.MethodsPeripheral blood samples were collected from Japanese patients with primary open-angle glaucoma (n = 206), exfoliation syndrome (n = 199), and controls (n = 126). Serum levels of lipid peroxides, ferric-reducing activity, and thiol antioxidant activity were measured by diacron reactive oxygen metabolite (dROM), biological antioxidant potential (BAP), and sulfhydryl (SH) tests, respectively, using a free radical analyzer. To test the possible effect of oxidative stress on IOP levels, the patients were classified into one of four groups (Q1, Q2, Q3, and Q4, with Q1 having the lowest IOP) based on the quartile value of IOP. For this classification, the known highest IOP value in both the right and left eyes was regarded as each subject’s IOP. For comparisons among the IOP groups, the differences were calculated using one-way analysis of variance followed by post-hoc unpaired t-tests. To adjust for differences in demographic characteristic distributions, the dROM, BAP, and SH test values were compared among the IOP groups using multiple logistic regression analysis; the odds ratio (OR) of each variable was calculated with the Q1 group as the reference.ResultsThe dROM and the SH levels did not differ significantly (p = 0.6704 and p = 0.6376, respectively) among the four IOP groups. The BAP levels differed significantly (p = 0.0115) among the four IOP groups; the value was significantly lower in the Q4 group (1,932 μmol/L) compared with the Q1 (2,023 μmol/L, p = 0.0042) and Q2 (2,003 μmol/L, p = 0.0302) groups and significantly lower in the Q3 group (1,948 μmol/L) than the Q1 (p = 0.0174) group. After adjustment for differences in various demographic characteristics, lower BAP values were significantly associated with the classification into higher IOP groups (Q3 group, p = 0.0261 and OR = 0.06/range; Q4 group, p = 0.0018 and OR = 0.04/range). The dROM and SH values did not reach significance in any comparisons.ConclusionsLower systemic antioxidant capacity measured by ferric-reducing activity is involved in the pathogenesis of open-angle glaucoma via its roles in IOP elevation.

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“…The eye is an exceptional organ because of its continuous exposure to environmental chemicals, radiation, and atmospheric oxygen. Oxidative stress mechanisms in ocular tissues have been hypothesized to play a role in diseases such as cataracts, glaucoma, uveitis, pseudoexfoliation syndrome, and age-related macular degeneration [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Mobile Phones on Oxidant/Antioxidant Balance in Cornea and Lens of Rats

Balcı

Devrım

Durak

2007

Current Eye Research

108

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Protein carbonyl levels in the aqueous humour and serum of patients with pseudoexfoliation syndrome

Cited by 24 publications

References 28 publications

Association between systemic oxidative stress and visual field damage in open-angle glaucoma

Association between systemic oxidative stress and visual field damage in open-angle glaucoma

Correlation between Systemic Oxidative Stress and Intraocular Pressure Level

Effects of Mobile Phones on Oxidant/Antioxidant Balance in Cornea and Lens of Rats

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