Protein C preserves microcirculation in a model of neonatal septic shock

Fischer, Doris; Nold, Marcel F.; Nold-Petry, Claudia A.; Furlan, Antonio; Veldman, Alex

doi:10.2147/vhrm.s5863

Cited by 5 publications

(1 citation statement)

References 23 publications

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“…However, emotions measured by technical sensors cannot be unambiguously correlated with the type of emotion people experience and the context of that particular emotion [17]. Moreover, most research has aimed at assessing spatial-emotional interactions and has focused on the individual perspective, only a few studies have attempted to aggregately map the emotional patterns of multiple individuals throughout the urban fabric [27][28][29][30]. Using an ambulatory sensing device for collecting physiological measurements, a dedicated smartphone app, and surveys, Shoval et.al.…”

Section: Theoretical Background 21 Urban Emotions and Emotional Commu...mentioning

confidence: 99%

Historical Buildings and Monuments as Cultural Heritage In Situ—Perspectives from a Medium-Sized City

2023

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The research presents the results of a survey carried on in Craiova, one of the largest Romanian cities, which contains numerous buildings from the late 19th and early 20th centuries, some of which were reconsolidated and brought back to use, while others are still decaying. The aim was to spatially investigate residents’ perceptions of the built heritage in the historical city center of Craiova based on questionnaires and mapping perceptions using the Emotional GIS (EGIS) methodology proposed by Wang (2021) and the extent to which this heritage could be a valuable asset for cultural tourism. The alteration of function as well as the context for part of the historical area of the city center testify to the musealization of the study area. The large number of buildings included on the heritage list outlines the characteristics of a living open-air museum, capitalizing on the heritage in situ.

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Section: Theoretical Background 21 Urban Emotions and Emotional Commu...mentioning

confidence: 99%

Historical Buildings and Monuments as Cultural Heritage In Situ—Perspectives from a Medium-Sized City

2023

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The benefits, limitations and opportunities of preclinical models for neonatal drug development

Campion

Inselman

Hayes

et al. 2022

Disease Models &Amp; Mechanisms

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Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, perinatal hypoxic–ischemic encephalopathy and neonatal sepsis – and the available in vivo, in vitro and in silico preclinical models for studying these diseases. Better understanding of the strengths and weaknesses of specialized neonatal disease models will help to improve their utility, may add to the understanding of the mode of action and efficacy of a therapeutic, and/or may improve the understanding of the disease pathology to aid in identification of new therapeutic targets. Although the diseases covered in this article are diverse and require specific approaches, several high-level, overarching key lessons can be learned by evaluating the strengths, weaknesses and gaps in the available models. This Review is intended to help guide current and future researchers toward successful development of therapeutics in these areas of high unmet medical need.

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Clinical evaluation of the intestinal microcirculation using sidestream dark field imaging – Recommendations of a round table meeting

Lehmann

Abdo

Kern

et al. 2014

Clinical Hemorheology and Microcirculation

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INTRODUCTION:In clinical setting, Sidestream Dark Field (SDF) imaging has provided unprecedented insights into the gut microcirculation mainly by studying the intestinal mucosa of patients with ileostomies. Visualizing microvascular structure and function of ileal mucosa at the bedside brings unique opportunity for clinical research, particularly in critically ill patients. Several papers that were focused on intestinal microcirculation, used different methods of assessment because an accepted scoring systems does not exist so far and it is no surprise that it is rather difficult to compare the results from these studies. The present paper presents recommendations concerning specific aspects of image acquisition and proposes some parameters for the description of the intestinal microcirculation in human studies, as suggested by the participants of a round table meeting. METHODS: The round table meeting participants reviewed all relevant literature, discussed various aspects of image acquisition by SDF technology in patients with ileostomy and parameters for the description of intestinal mucosa microcirculation. Selected key conditions for high quality and reproducible image recordings were identified. To evaluate quality of intestinal microcirculation, selected parameters and scoring system were suggested and described. RESULTS: For image acquisition in ileostomies, five key points were proposed: optimal timing, optimal SDF device probe positioning, optimal stabilization, optimal number and length of acquired video recordings, and optimal avoidance of pressure artefacts. With regard to image analysis, simplified set of quantitative and qualitative parameters for the description of the intestinal mucosa microcirculation for the clinical studies has been proposed: vessels per villus, microvascular flow index, proportion of perfused villi, and borders of villi. The proposed parameters can be included in a semi-quantitative scoring system; Ch. Lehmann et al. / Clinical evaluation of the intestinal microcirculation using sidestream dark field imaginghowever, this scoring system needs further validation. This simplified analysis does not require sophisticated software and can be performed manually on the video screen. CONCLUSION: We propose a simple methodology for image acquisition and suggest specific microvascular parameters to analyze SDF imaging studies of the intestinal mucosa microcirculation in patients with ileostomy. Proposed scoring system needs to be validated in further clinical studies.

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Protein C preserves microcirculation in a model of neonatal septic shock

Cited by 5 publications

References 23 publications

Historical Buildings and Monuments as Cultural Heritage In Situ—Perspectives from a Medium-Sized City

Historical Buildings and Monuments as Cultural Heritage In Situ—Perspectives from a Medium-Sized City

The benefits, limitations and opportunities of preclinical models for neonatal drug development

Clinical evaluation of the intestinal microcirculation using sidestream dark field imaging – Recommendations of a round table meeting

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