Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis

Kanosue, Kiyoko; Nagaya, Satomi; Morishita, Eriko; Yamanishi, M.; Imashuku, Shinsaku

doi:10.1055/s-0041-1728664

Cited by 1 publication

(1 citation statement)

References 13 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clostridia (especially Clostridium di cile and Clostridium perfringens) were found to be associated with thrombotic events such as VTE, portal vein thrombosis, superior mesenteric vein thrombus, and visceral vein thrombosis [44][45][46][47][48]. Additionally, in vitro and animal studies have indicated that platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a negative regulatory role in thrombus formation [49,50], while the binding of Clostridium perfringens βtoxin to PECAM-1 induces the formation of cellular membrane pores, thereby interfering with the function of PECAM-1 [51].…”

Section: Discussionmentioning

confidence: 99%

Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on venous thromboembolism

Cheng,

He,

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Although there is considerable evidence suggesting a link between gut microbiota (GM) composition and venous thromboembolism (VTE)/deep vein thrombosis (DVT)/pulmonary embolism (PE), population-level studies that can establish a causal relationship are currently lacking. Methods Using two-sample Mendelian randomization (MR) approach was used to examine the causal effects of 211 GM and 489 plasma metabolites on VTE/PE/DVT. We employed instrumental variables comprised of single nucleotide polymorphisms (SNPs) strongly associated with GM composition and plasma metabolite levels to determine whether these factors play a causal role in the development of VTE/DVT/PE. Additionally, we conducted mediation analysis to explore the potential associations between specific taxonomic groups and metabolites. Results The MR analysis revealed significant associations between 16 taxonomic units and 40 metabolites with VTE/DVT/PE as the causative factors. Among these, Firmicutes, Clostridia, Roseburia, Ruminococcaceae NK4A214, and Intestinimonas were found to have a protective effect against VTE/DVT/PE. In contrast, Bacteroidetes, Anaerotruncus, Victivallales, Desulfovibrionaceae, Clostridium innocuum, Eubacterium oxidoreducens, and Lachnoclostridium have been identified as risk factors for VTE/DVT/PE. Reverse MR analysis revealed 11 associations between VTE/DVT/PE and GM. Furthermore, no significant heterogeneity or horizontal pleiotropy was observed in any of the instrumental variables. Mediation analysis revealed 10 intermediate relationships, and metabolic pathway analysis identified 6 significant pathways. Conclusions Our study emphasizes the significant causal associations between the gut microbiota (GM), plasma metabolome, and VTE/DVT/PE. These interconnections have the potential to be used as clinical biomarkers for risk stratification and prognosis assessment in patients with VTE/DVT/PE.

show abstract