Protein C activity in renal disease

Inhibitors of Coagulation in Terminal Renal Failure and during Hemodialysis

“…The present results confirm and extend our previous findings regarding changes in immunoreactive protein C and protein C activity in renal failure and during hemodi alysis [6,7].…”

“…We have earlier found a decreasing protein C activity with progressive renal failure [7] and a low activity, des pite normal antigen levels, in hemodialysis patients [6], pointing to the existence of a hitherto unknown inhibitor of protein C in uremic plasma. Our results further suggest that this inhibitor may be removed, at last partly, by hemodialysis.…”

Defective Protein C in Uraemia

“…Previously we found low protein C activ ity in chronic renal failure [14] and terminal uraemia requiring haemodialysis [16]. A cor relation between an increase in serum creati nine and a decrease in protein C activity was demonstrated in patients with chronic renal failure [14], Furthermore, during dialysis an increase in protein C activity (averaging 50%) was noted, indicating a removal by dialysis of one or more inhibitors in plasma [16].…”

“…In uraemic patients concomi tant bleeding problems and thrombotic dis orders have been described [10][11][12][13]. This paradox is not fully understood, but we have recently reported low protein C activity in chronic renal failure [14] and suggested it to be a contributing factor to thrombotic com plications. In order to further elucidate the mechanism leading to decreased protein C activity in uraemia we have assayed antigen level and activity of protein C in haemodial ysis patients.…”

Further Investigations of the Defective Protein C in Hemodialysis, Hemofiltration and Continuous Ambulatory Peritoneal Dialysis

“…During a hemodial ysis treatment the protein C activity in creases [14] a finding which is confirmed by the present study. Furthermore, changes in protein C coagulant activity seem closely re lated to changes in kidney function as mea sured by se-creatinine in both chronic pro gressive renal failure [ 15], acute renal failure [16], and during acute and chronic rejection episodes after kidney transplantation [unpubl. data; 17].…”