Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona
Radha P. Somarathne,
Dhanush L. Amarasekara,
Chathuri S. Kariyawasam
et al.
Abstract:Understanding the conformation of proteins in the nanoparticle corona has important implications in how organisms respond to nanoparticle‐based drugs. These proteins coat the nanoparticle surface, and their properties will influence the nanoparticle's interaction with cell targets and the immune system. While some coronas are thought to be disordered, two key unanswered questions are the degree of disorder and solvent accessibility. Here, a model is developed for protein corona disorder in polystyrene nanopart… Show more
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