Protein-binding and urinary excretion of 99mTc(Sn)-MDP and 99mTc-MDP

Savelkoul, T.J.F.; Ginkel, J.J. van; Grouls, R. J. E.; Oldenburg, S.J.; Duursma, S. A.

doi:10.1016/0047-0740(85)90167-6

Cited by 5 publications

(1 citation statement)

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“…Another study was carried out that referred to the contribution of Sn 2+ ions in the accumulation of 99m-Technetium-MDP, where Sn 2+ ions act as reducing agents that permeated conversion of pertechnetate ( 99m TcO 4 − ) to technetium (III) ( 99m TcO 3 − ), furthermore, formation of lipophillic 99m Tc-Sn(OH) 2+ complexes, that crosses blood brain barrier due to lipid solubility and allowing them into 'calvaria' which means the top part of the brain. [25] It appears from the above discussion that percentage of induced dose or uptake of radiation may be dependent on bone infrastructure, number of bones and organ weight. It is also vital to consider the physiologic and pathologic condition of the patient, disease state, metabolism rate, diffusion of oxygen from the blood to tissue and functions of various tissues.…”

Section: Results Discussionmentioning

confidence: 98%

Comprehensive Analysis and Quality Assessment of Freeze Dried Methylene Diphosphonate Labelled with 99m-Technetium: An Extensive Comparison of Biodistribution Study with Commercial Standards

Tasnim,

Akhter,

Rahman

et al. 2023

Preprint

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Objective:Technetium-99m (99mTc) is an important radionuclide used for the prognosis of bone scintigraphy labelled with a suitable kit. Methodology: The present investigations focus on the aseptic preparation and application of the methylene di-phosphonic acid (MDP) kit on bio-organ after labeling with 99mTc collected from a 99Mo/99mTc generator. Result:Before going to bio-application of the labelled kit, radiochemical purity was determined by paper chromatography using the High Purity Germanium (HPGe) detector and the radiochemical purity of 99mTc-MDP was found to be 99%. Furthermore, negative results were found for pyrogen and bacterial endotoxin tests; fungal growth was also absent. Radiation dose uptake in different organs of Wister rats was measured by a dose calibrator, and observed results indicate the highest accumulation of 99mTc-MDP in the skull and skeletal part. This study also performed a comparative study model between laboratory and commercially prepared Monrol MDP kits. This study was performed as bio-application of laboratory prepared 99mTc-MDP prior to commercial production of cold kit at radioisotope production division of Bangladesh Atomic Energy Commission. Conclusion: Overall, the observations from this study are within the accepted range and provide prospect for commercial production of the kits for human administration.

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Section: Results Discussionmentioning

confidence: 98%