“…Its modular architecture allows for interactions with different binding partners during the various steps of the formation of the active replication forks and coupling to other cellular events (3,15,17,20,22,29,30). In E. coli, DnaA III interactions with itself, Hda, or DnaC are important for the spatial positioning of the ATP-DnaA molecules and their recycling (13,17,31,32). Protein-protein interactions involving DnaA I-II play critical roles in DnaA self-oligomerization, helicase loading (7,10,17), and regulation of the replication timing (16,28).…”