Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy

Graphene is a two-dimensional atomic crystal, and since its development it has been applied in many novel ways in both research and industry. Graphene possesses unique properties, and it has been used in many applications including sensors, batteries, fuel cells, supercapacitors, transistors, components of high-strength machinery, and display screens in mobile devices. In the past decade, the biomedical applications of graphene have attracted much interest. Graphene has been reported to have antibacterial, antiplatelet, and anticancer activities. Several salient features of graphene make it a potential candidate for biological and biomedical applications. The synthesis, toxicity, biocompatibility, and biomedical applications of graphene are fundamental issues that require thorough investigation in any kind of applications related to human welfare. Therefore, this review addresses the various methods available for the synthesis of graphene, with special reference to biological synthesis, and highlights the biological applications of graphene with a focus on cancer therapy, drug delivery, bio-imaging, and tissue engineering, together with a brief discussion of the challenges and future perspectives of graphene. We hope to provide a comprehensive review of the latest progress in research on graphene, from synthesis to applications.

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“…In addition, the photothermal effect of nano-rGO could efficiently destroy cancer cells. 210 Reduced graphene oxide …”

Section: Biomedical Applications Of Graphenementioning

confidence: 99%

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Gurunathan¹,

Kim²

2016

IJN

228

129

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“…Another commonly used method is thermal reduction by heating GO to above 1000 °C [22,52,53]. Besides, some other novel reduction methods, such as the photo-catalytic method [54][55][56], biomolecule-assisted methods [57,58], plant extract method [59], supercritical fluid method [60] and electrochemical method [61], were proposed for the reduction of GO. [34,62], respectively).…”

Section: Rgomentioning

confidence: 99%

The Preparation of Graphene Oxide and Its Derivatives and Their Application in Bio-Tribological Systems

et al. 2014

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Graphene oxide (GO) can be readily modified for particular applications due to the existence of abundant oxygen-containing functional groups. Graphene oxide-based materials (GOBMs), which are biocompatible and hydrophilic, have wide potential applications in biomedical engineering and biotechnology. In this review, the preparation and characterization of GO and its derivatives are discussed at first. Subsequently, the biocompatibility and tribological behavior of GOBMs are reviewed. Finally, the applications of GOBMs as lubricants in bio-tribological systems are discussed in detail.

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“…36 Effects of NIR irradiation on temperature changes in nGO and nGO@DOX-cPEG dispersions were evaluated, as presented in Figure 3d; GO can increase temperature by energy transfer through π-network restorationmediated light absorption to heat. 37 The temperature increase patterns of the two dispersions were similar during NIR irradiation (0-5 min) and the local temperature reached~50°C for nGO@DOX-cPEG flakes. This temperature increase may lead to combined anticancer activity with DOX.…”

Section: Resultsmentioning

confidence: 82%

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

Thapa

Byeon

et al. 2017

NPG Asia Mater

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Near-infrared (NIR)-induced chemothermal doxorubicin (DOX) release for anticancer activity was demonstrated using DOX-incorporated fully lateral nanodimensional graphene oxide (nGO) flakes layered with chitosan-polyethylene glycol (PEG) conjugate (nGO@DOX-cPEG) from a single-pass gas-phase self-assembly. Unlike most previously reported graphene oxide-based drug carriers, the proposed processing method introduced a fully nanoscale (both in lateral dimension and thickness) configuration without multistep wet physicochemical processes that enhance the drug-loading capacity and NIR-induced heat generation resulting from the increased surface area. The accumulation of nGO@DOX-cPEG flakes in prostate cancer cells enhanced apoptotic phenomena via the combined effects of DOX release and heat generation upon NIR irradiation. The combined anticancer effects were verified through in vivo assessment with better safety profiles than free DOX. The proposed strategy warrants continuous assembly of multimodal nanocarriers for the efficient treatment of prostate cancers and may be a promising candidate for advanced drug delivery systems.

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Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy

Cited by 266 publications

References 33 publications

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

The Preparation of Graphene Oxide and Its Derivatives and Their Application in Bio-Tribological Systems

Easy on-demand self-assembly of lateral nanodimensional hybrid graphene oxide flakes for near-infrared-induced chemothermal therapy

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