Protein arginine phosphorylation in organisms

Huang, Biling; Zhao, Zhixing; Zhao, Yufen; Huang, Shaohua

doi:10.1016/j.ijbiomac.2021.01.015

Cited by 22 publications

(10 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The arginine phosphatase (lmo2540) is the next important protein for bacteria stress response. It modulates the arginine phosphorylation states of regulators such as the stress response regulator CtsR and the global regulator MgrA, particularly in response to oxidative stress [70]. Thus, using the example of the most represented categories of COG, we have shown the importance of genes affected by mutations for the vital activity of L. monocytogenes ST7.…”

Section: Possible Functional Role Of Mutated Genesmentioning

confidence: 93%

Genomic characteristics of listeria that caused invasive listeriosis during the COVID-19 pandemic

Voronina

Kunda

Рыжова

et al. 2022

Preprint

View full text Add to dashboard Cite

Invasive listeriosis is relatively rare, but is one of the deadliest food-borne infections, affecting pregnant women, their fetuses and newborn infants, the elderly and immunocompromised people. The aim of this study was to research the impact of the COVID-19 pandemic on invasive listeriosis in the metropolis. Loci and whole-genome sequencing with subsequent bioinformatic analysis were used for the study of clinical and food Listeria monocytogenes isolates revealed in 2018–2022. The results indicate the crucial change in the spectrum of the L. monocytogenes sequence types (ST) causing invasive listeriosis during the COVID-19 pandemic, with slight changes in the ST spectrum of the food isolates. An increase in sensitivity to previously non-human L. monocytogenes genotypes, namely ST8, 20, 21, 37, 391, and 425, was observed. L. monocytogenes of ST20 and 425 carried plasmids with virulence factors (VF), in addition to the 42 VF identified in the genomes with the vip gene exclusion in the genomes of ST7, 8, 21, and 37. Perinatal listeriosis cases were associated with the new hypervirulent L. monocytogenes of ST1, 4, and 219 compiled with old ST6. These data indicate the need for the more stringent control of food products for high-risk groups.

show abstract

Section: Possible Functional Role Of Mutated Genesmentioning

confidence: 93%

Genomic characteristics of listeria that caused invasive listeriosis during the COVID-19 pandemic

Voronina

Kunda

Рыжова

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…e phosphorylation of proteins is one of the most basic, common, and important mechanisms for the regulation of protein activities and functions [6,7]. e initiation or close of multiple types of biochemical functions can be regulated by the phosphorylation of proteins, such as the transcription and translation regulation, signal transduction, DNA damage repair, cell metabolism, secretion, and homeostasis [8].…”

Section: Introductionmentioning

confidence: 99%

Investigations on the Changes of Serum Proteins in Rabbits after Trimeresurus stejnegeri Venom Injection via Mass Spectrometry-Based Proteomics

Wang

Yang

Shi

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Purpose. There are few studies on protein phosphorylation in the process of snake poisoning. The purpose of this study was to investigate the toxic mechanism of Trimeresurus stejnegeri at the protein level by determining the differential expression of phosphorylated proteins in rabbits after poisoning using proteomics. Methods. The Trimeresurus stejnegeri venom model in rabbits was established by intramuscular injection of 20 mg/kg venom. The serum was collected and the differential expression of phosphorylated proteins in the serum was determined by the iTRAQ technology, TiO2 enriched phosphorylated peptides, and the mass spectrometry analysis. The functional analysis was conducted using ClueGO software and the related mechanism was evaluated by the network analysis of biological interaction. The expression level of related proteins was determined by the Western blotting assay. Results. Compared to the control group, 77 differentially expressed proteins were observed in the model group. These proteins were closely associated with the complement and agglomerate cascade signaling pathways, the HIF signaling pathway, the pentose phosphate pathway, and the cholesterol metabolism signaling pathway. According to the results of network analysis, TF and SCL16A1 were determined as the core proteins, which were identified by the Western blotting assay. Conclusion. The present study provided valuable phosphorylation signal transduction resources for investigating the toxic mechanism and the therapies for Trimeresurus stejnegeri poisoning.

show abstract

“…This is achieved through the covalent attachment of phosphate groups to serine, threonine, and tyrosine residues by protein kinases, and their removal by protein phosphatases. (50,51) Several changes in the phosphorylation profile were observed among the different Leishmania parasite stages, confirming the importance of this modification during parasite adaptation throughout their life cycle, (46,47,52) and opening the opportunity to explore the repertoire of kinases and phosphatases as drug targets, as has been done extensively for the treatment of a variety of diseases in humans. (53) The Leishmania kinome has 195 eukaryotic protein kinases (ePKs) that are classified according to catalytic domain conservation in six groups (CMGC, AGC, CAMK, STE, NEK, CK1).…”

Section: Drug Target Validation and The Prospection Of New Antileishm...mentioning

confidence: 83%

Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress

Monte-Neto

Moreira

Sousa

et al. 2022

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Despite the increasing number of manuscripts describing potential alternative antileishmanial compounds, little is advancing on translating these knowledges to new products to treat leishmaniasis. This is in part due to the lack of standardisations during pre-clinical drug discovery stage and also depends on the alignment of goals among universities/research centers, government and pharmaceutical industry. Inspired or not by drug repurposing, metal-based antileishmanial drugs represent a class that deserves more attention on its use for leishmaniasis chemotherapy. Together with new chemical entities, progresses have been made on the knowledge of parasite-specific drug targets specially after using CRISPR/Cas system for functional studies. In this regard, Leishmania parasites undergoe post-translational modification as key regulators in several cellular processes, which represents an entire new field for drug target elucidation, once this is poorly explored. This perspective review describes the advances on antileishmanial metallodrugs and the elucidation of drug targets based on post-translational modifications, highlighting the limitations on the drug discovery/development process and suggesting standardisations focused on products addressed to who need it most.

show abstract

Protein arginine phosphorylation in organisms

Cited by 22 publications

References 77 publications

Genomic characteristics of listeria that caused invasive listeriosis during the COVID-19 pandemic

Genomic characteristics of listeria that caused invasive listeriosis during the COVID-19 pandemic

Investigations on the Changes of Serum Proteins in Rabbits after Trimeresurus stejnegeri Venom Injection via Mass Spectrometry-Based Proteomics

Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress

Contact Info

Product

Resources

About