Protein Arginine Methyltransferase CARM1 in Human Breast Cancer
Megan Bacabac,
Peng Liu,
Wei Xu
Abstract:Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that deposits asymmetrical dimethylation marks on both histone and nonhistone substrates. The regulatory role of CARM1 in transcription was first identified in estrogen receptor positive (ER+) breast cancer. Since then, the mechanism of CARM1 in activating ER-target genes has been further interrogated. CARM1 is expressed at the highest level in ER negative (ER–) breast cancer and higher expression correlates wit… Show more
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