Protein and cell micropatterning and its integration with micro/nanoparticles assembly

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The physico-chemical, mechanical, and biological advantages of incorporating nanoscale bioactive glasses in such biodegradable nanocomposites are discussed and the possibilities to expand the use of these materials in other nanotechnology concepts aimed to be used in different biomedical applications are also highlighted. ACCEPTED MANUSCRIPT

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“…Applications in the biomedical field for silica nanoparticles have been discussed in the literature (see for example refs. [43][44][45][46]). …”

Section: Sol-gel Techniquesmentioning

confidence: 99%

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Boccaccını

Erol

Stark

et al. 2010

Composites Science and Technology

460

287

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“…BioMEMS and μF research have provided a plethora of ways to explore how cells respond to micrometer-scale modifications of their physical and chemical environments. [76][77][78][79][80][81] Because microfabrication allows creation of cell culture environments that are well-defined with micrometer precision, quantitative characterization and experimental reproducibility are greatly enhanced.…”

Section: Microfluidic Methodsmentioning

confidence: 99%

Biomolecular gradients in cell culture systems

2008

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Biomolecule gradients have been shown to play roles in a wide range of biological processes including development, inflammation, wound healing, and cancer metastasis. Elucidation of these phenomena requires the ability to expose cells to biomolecule gradients that are quantifiable, controllable, and mimic those that are present in vivo. Here we review the major biological phenomena in which biomolecule gradients are employed, traditional in vitro gradient-generating methods developed over the past 50 years, and new microfluidic devices for generating gradients. Microfluidic gradient generators offer greater levels of precision, quantitation, and spatiotemporal gradient control than traditional methods, and may greatly enhance our understanding of many biological phenomena. For each method, we outline the salient features, capabilities, and applications.

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“…Advantages of these structures are expected being originated from unique properties of biomolecules such as proteins, desoxyribonucleic acid (DNA), and redox enzymes [1][2][3][4][5]. Integration of the biomolecules within solid nanostructures introduces biochemical recognition in the technology and functioning of the devices.…”

Section: Introductionmentioning

confidence: 99%

“…Components of electronic circuits, sensors, and actuators can be created by nanotechnology and selfassemblage of supramolecules [1,2]. Properties of solid nanoobjects can be significantly modified by biomolecules [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Scanning probe microscopic and optical detection of DNA integration within multicomponent structures on Si surfaces

Bukauskas¹

2008

Lithuanian J. Phys.

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Self-arrangement of DNA based structures on clean mica and modified Si surfaces is investigated by means of scanning probe microscope (SPM) and spectroscopic ellipsometry (SE) method. DNA strands are deposited from a colloidal solution on solid surfaces at room temperature. Surfaces of solid substrates and biomolecular structures are additionally modified by Ag nanoparticles. The self-arranged surface structures are visualized by SPM. The effect of the multicomponent structures on the optical response of complex hybrid structures is studied. Changes in the optical response of the hybrid samples are related to the contributions of self-assembled DNA-based structures and Ag nanoparticles on the Si surfaces. Binding of Ag nanoparticles to the DNA strands and formation of well-ordered structures on the surfaces with DNA are discussed.

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Protein and cell micropatterning and its integration with micro/nanoparticles assembly

Cited by 144 publications

References 92 publications

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Polymer/bioactive glass nanocomposites for biomedical applications: A review

Biomolecular gradients in cell culture systems

Scanning probe microscopic and optical detection of DNA integration within multicomponent structures on Si surfaces

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