Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice

Robertson, Lauren; Treviño-Villarreal, J. Humberto; Mejia, Pedro; Grondin, Yohann; Harputlugil, Eylul; Hine, Christopher; Vargas, Dorathy; Zheng, Hui; Ozaki, C. Keith; Kristal, Bruce S.; Simpson, Stephen J.; Mitchell, James R.

doi:10.3945/jn.114.199380

Cited by 78 publications

(83 citation statements)

References 49 publications

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“…In the breast cancer model, this effect was partially mediated by the downregulation of the stress-responsive enzyme heme oxygenase-1 in cancerous cells (Di Biase et al, 2016). Furthermore, diets reduced in or lacking protein or essential amino acids have similar beneficial effects on metabolism and stress resistance (Robertson et al, 2015), and because they can be fed on an ad libitum basis, may also function in the context of preconditioning prior to elective surgery. Taken together, these results indicate that PF and FMD have the potential to play an important complementary role in medicine by increasing stress resistance, promoting disease prevention, enhancing disease treatment, stimulating stem cell-based regeneration and delaying the aging process.…”

Section: Discussionmentioning

confidence: 99%

“…Two of the earliest demonstrations that long-term CR (lasting 3 months or more) confer resistance to clinically relevant acute stressors were performed in models of stroke and myocardial infarction (Chandrasekar et al, 2001; Yu and Mattson, 1999). Shorter periods of more severe CR, such as one or two weeks of 50% CR, also protect from liver and kidney IRI (Mitchell et al, 2010; Robertson et al, 2015), as do regimens involving total protein or essential amino acid deprivation (Harputlugil et al, 2014; Hine et al, 2015; Peng et al, 2012; Robertson et al, 2015). …”

Section: Dietary Preconditioning Against Surgical Stressmentioning

confidence: 99%

“…Mechanistically, the protection afforded by protein and essential amino acid restriction appears to overlap that of fasting, for example in its association with reduced circulating growth factor signaling through insulin, IGF-1 and leptin (Harputlugil et al, 2014; Robertson et al, 2015). In the liver, protein restriction leads to improved hepatic insulin sensitivity prior to ischemia and increased pro-survival signaling through the Akt pathway after reperfusion, resulting in increased hepatocellular stress resistance.…”

Section: Dietary Preconditioning Against Surgical Stressmentioning

confidence: 99%

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Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Brandhorst

Harputlugil

Mitchell

et al. 2017

Ageing Research Reviews

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Reduced caloric intake including fasting, as well as the dietary composition or the timing of food intake, impact longevity, likely through a modification in the onset or the severity of chronic aging-related diseases such as cancer. As with pre- and post-operative dietary recommendations, evidence-based nutritional advice from healthcare professionals during and after cancer treatment is often vague or conflicting. We hypothesize that preventive dietary recommendations can help in the context of both chronic cancer treatment efficacy and the avoidance of development of secondary malignancies, as well as in the context of protection from the acute stress of surgery. In this perspective review, we will discuss the latest findings on the potential role of short-term dietary restriction in cancer treatment and improvement of surgical outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Dietary Preconditioning Against Surgical Stressmentioning

confidence: 99%

Section: Dietary Preconditioning Against Surgical Stressmentioning

confidence: 99%

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Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Brandhorst

Harputlugil

Mitchell

et al. 2017

Ageing Research Reviews

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“…Short-term DR or fasting prior to surgery preconditions against a variety of complications in preclinical models [6, 8, 10, 20, 23, 26]. Currently, the duration of preoperative fasting used as an “anesthetic precaution” in humans is likely too short to tap into DR benefits, while the progressive clinical application of ERAS nutritional guidelines promotes an alternate although not mutually exclusive concept of increased nutrition immediately prior to surgery.…”

Section: Discussionmentioning

confidence: 99%

“…In rodent models of surgical stress ranging from ischemia reperfusion injury (IRI) to vascular restenosis (intimal hyperplasia), short-term DR or fasting before surgery, followed by a return to normal food intake after surgery, leads to improved outcomes [6–10]. …”

Section: Introductionmentioning

confidence: 99%

Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review

Longchamp

Harputlugil²,

Corpataux³

et al. 2017

Gerontology

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Dietary restriction (DR) is best known for extending lifespan in experimental model organisms, but also increases resistance to a variety of clinically relevant stressors, including those associated with surgery. Extended periods of DR, lasting months to years, are required for optimal longevity benefits in rodents, but short-term dietary preconditioning (less than 1 week) remarkably protects from acute injury. Here, we discuss recent advances in our understanding of the mechanistic basis of short-term DR and fasting in the context of surgical stress resistance, including upstream amino acid sensing by the GCN2 and mTORC1 pathways, and downstream effector mechanisms including increased insulin-dependent prosurvival signaling and elevated endogenous hydrogen sulfide production. We also review the current trend in preoperative nutrition away from preoperative fasting and towards carbohydrate loading. Finally, we discuss the rationale for the nonmutually exclusive use of brief DR or pharmacological DR mimetics to precondition against the stress and potential complications of surgery.

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Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

Hegab

Ozaki

Meligy

et al. 2019

J Tissue Eng Regen Med

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Ageing is associated with decreased lung function and an increased incidence of lung infections. Several studies have suggested that long-term calorie restriction (CR) promotes health and longevity and results in the reduced risk of several diseases.The effect of CR is thought to be through improving the function of tissue stem cells.Stem cell function is known to decline with ageing. In this study, we examined the effects of ageing on lung epithelial and stem cells and the effect of CR on young and old lungs. We found that ageing results in a decrease in tracheal basal stem cells.CR induced an increase in basal stem cells in both young and old mice. In addition, ageing induced lung inflammation, and CR tended to reduce baseline lung inflammatory cell infiltration in young mice and significantly reduced ageing-induced lung inflammation. Furthermore, ageing reduced the number and function of mitochondria in lung and increased the level of mitochondrial reactive oxygen species. CR increased the number and function of mitochondria both in young and old mice. Moreover, ageing reduced lung stem cell colony-forming efficiency (CFE), and CR increased the CFE in both young and old mice. Finally, CR improved epithelial cell survival in injured lungs of young mice. In conclusion, ageing causes several structural and functional changes/impairments in lung epithelial cells. CR induces several potentially beneficial changes in lung epithelial cells, even when it is initiated at an older age, including reversal of some ageing-induced changes.

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Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice

Abstract: In male mice, PR and CR both contributed to the benefits of short-term DR against renal IRI independent of GCN2 but partially dependent on reduced circulating leptin and coincident with AMPK activation and mTORC1 repression.

Cited by 78 publications

References 49 publications

Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Protective effects of short-term dietary restriction in surgical stress and chemotherapy

Is Overnight Fasting before Surgery Too Much or Not Enough? How Basic Aging Research Can Guide Preoperative Nutritional Recommendations to Improve Surgical Outcomes: A Mini-Review

Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

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