Protein adsorption under electrical stimulation of neural probe coated with polyaniline

Wang, Liping; Wang, Wei; Di, Ling; Lu, Ya-Nan; Wang, Jin‐Ye

doi:10.1016/j.colsurfb.2010.05.034

Cited by 43 publications

(34 citation statements)

References 27 publications

(27 reference statements)

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“…These results suggest that CP and hybrid films adsorb BSA at the surface, even though with different abilities. This hypothesis is supported by recent studies using CPs based on PPy and polyaniline . In order to provide indirect evidences of our assumption, PEDOT * , PEDOT‐I * , and PEDOT‐II * samples were immersed in SBF + BSA for 3 min, and after drying, the contact angles for pure water were measured and compared with those obtained without any previous treatment.…”

Section: Resultssupporting

confidence: 77%

Electro‐biocompatibility of conjugates designed by chemical similarity

Maione

Fabregat

Valle

et al. 2014

Journal of Peptide Science

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The roughness and thickness of films formed by hybrid conjugates prepared by coupling poly(3,4-ethylenedioxythiophene) and synthetic amino acids bearing a 3,4-ethylenedioxythiophene group in the side chain have been significantly increased using a new synthetic approach. This procedure also provoked a more effective incorporation of the amino acid at the end of the polymer chains, as has been reflected by the electronic and electrochemical properties. Although the surface polarity of all these materials is similar to that of formamide, the hydrophilicity of the conjugates is higher than that of the conducting polymer. The surface energy of all the investigated systems is dominated by the dispersive component, even though the role played by the polar contribution is more important for the conjugates than for the conducting polymer. On the other hand, all the prepared materials behave as bioactive matrices. The electrochemical response of the conjugates coated with cells reflects the electro-compatibility of these two-component substrates. Thus, the ability to exchange charge reversibly of all conjugates increases considerably when they are coated with cellular monolayers, which has attributed to favorable interactions at the interface formed by the conjugate surface and the cellular monolayer.

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Section: Resultssupporting

confidence: 77%

Electro‐biocompatibility of conjugates designed by chemical similarity

Maione

Fabregat

Valle

et al. 2014

Journal of Peptide Science

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“…[54][55][56][57] Given that histology showed all axons growing in the middle of conduit, it is doubtful that regenerating axons extensively interacted directly with the inner wall of the conduit. Protein adsorption to biomaterials is known to play a significant role in the final regenerative outcome of a nerve conduit, as it is one of initial events post-implantation, and influences later biological events, such as cell attachment and …”

Section: Discussionmentioning

confidence: 99%

Enhanced Femoral Nerve Regeneration After Tubulization with a Tyrosine-Derived Polycarbonate Terpolymer: Effects of Protein Adsorption and Independence of Conduit Porosity

Ezra

Bushman

Shreiber

et al. 2013

Tissue Engineering Part A

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Following complete nerve transection, entubulation of the nerve stumps helps guide axons to reconnect distally. In this study, a biodegradable and noncytotoxic tyrosine-derived polycarbonate terpolymer composed of 89.5 mol% desaminotyrosyl tyrosine ethyl ester (DTE), 10 mol% desaminotyrosyl tyrosine (DT), and 0.5 mol% poly(ethylene glycol) (PEG, molecular weight [Mw] = 1 kDa) [designated as E10-0.5(1K)] was used to fabricate conduits for peripheral nerve regeneration. These conduits were evaluated against commercially available nonporous polyethylene (PE) tubes. The two materials are characterized in vitro for differences in surface properties, and the conduits are then evaluated in vivo in a critical-sized nerve defect in the mouse femoral nerve model. Conduits were fabricated from E10-0.5(1K) in both porous [P-E10-0.5(1K)] and nonporous [NP-E10-0.5(1K)] configurations. The results illustrate that adsorption of laminin, fibronectin, and collagen type I was enhanced on E10-0.5(1K) compared to PE. In addition, in vivo the E10-0.5(1K) conduits improved functional recovery over PE conduits, producing regenerated nerves with a fivefold increase in the number of axons, and an eightfold increase in the percentage of myelinated axons. These increases were observed for both P-E10-0.5(1K) and NP-E10-0.5(1K) after 15 weeks. When conduits were removed at 7 or 14 days following implantation, an increase in Schwann cell proteins and fibrin matrix formation was observed in E10-0.5(1K) conduits over PE conduits. These results indicate that E10-0.5(1K) is a pro-regenerative material for peripheral nerves and that the porosity of P-E10-0.5(1K) conduits was inconsequential in this model of nerve injury.

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“…The films had anti‐eroding properties. In this work, PANI nanoparticles increased protein adsorption and improved the biocompatibility of the tissue‐implant interface . Moreover, in contrast to uncoated platinum electrodes, the increased surface roughness and surface energy by PANI coatings promoted initial protein adsorption.…”

Section: Cnms Used In Neural Probesmentioning

confidence: 71%

“…These performances were able to facilitate specific protein interactions beneficial for cellular functions. Under the action of electrical stimulation, bovine serum albumin aggregates can form the nanostructure PANI films that can inhibit such aggregation, thus PANI nanoparticles can be used as a good coating material . Furthermore, it was found that the electrochemical modification of the electrode active area with poly(3,4‐ethylenedioxythiophene) (PEDOT) greatly decreased the electrical impedance.…”

Section: Cnms Used In Neural Probesmentioning

confidence: 99%