Protein adsorption resistible membrane for biosensor composed of polymer with phospholipid polar group

Ishihara, Kazuhíko; Ohta, Shin‐ichi; Yoshikawa, Tohru; Nakabayashi, Nobuo

doi:10.1002/pola.1992.080300524

Cited by 19 publications

(10 citation statements)

References 4 publications

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“…The amount of adsorbed protein on the original cellulose membrane was decreased significantly when the membrane was modified with the MPC polymers as shown in Table 2. We have already reported that the permeability of the cellulose membrane coated with poly-(MPC-co-BMA) was not lowered even in the presence of plasma proteins; however, that coated with poly (HEMA) decreased significantly (19). These findings strongly support the belief that the MPC polymer-modified cellulose membrane is suitable for use as a permeation membrane in the medical field in the presence of proteins.…”

Section: Modification Of Cellulose Membrane With Mpc Polymers and Itssupporting

confidence: 77%

“…Adsorption of plasma protein on MPC polymer modified cellulose membrane The adsorbed protein layer on the membrane surface affected not only the performance of the mem-brane regarding permeability of solutes but also blood compatibility (16). It was reported that a thick adsorbed protein layer (thickness above 700 A) was found on the cellulose hollow fiber membrane after hemodialysis (17)(18)(19). The amount of adsorbed protein on the original cellulose membrane was decreased significantly when the membrane was modified with the MPC polymers as shown in Table 2.…”

Section: Modification Of Cellulose Membrane With Mpc Polymers and Itsmentioning

confidence: 99%

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Hemocompatible Cellulose Dialysis Membranes Modified with Phospholipid Polymers

Ishihara

Nakabayashi

1995

Artificial Organs

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Hemocompatibility is one of the most important properties for hemodialysis membranes. For improvement of the hemocompatibility on a cellulose dialysis membrane, modifications with new blood-compatible phospholipid polymers were carried out. These methods included a direct grafting of the phospholipid monomer on the membrane surface, coating the membrane surface with a water-soluble graft copolymer composed of a cellulose backbone and phospholipid polymer as a branch, and covalent bonding with a reactive phospholipid polymer on the membrane surface. These modified membranes could reduce protein adsorption as well as complement activation and platelet adhesion on the surface without any adverse effects on the membrane performance.

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Section: Modification Of Cellulose Membrane With Mpc Polymers and Itssupporting

confidence: 77%

Section: Modification Of Cellulose Membrane With Mpc Polymers and Itsmentioning

confidence: 99%

Hemocompatible Cellulose Dialysis Membranes Modified with Phospholipid Polymers

Ishihara

Nakabayashi

1995

Artificial Organs

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“…From the shape of this curve, the diffusion coefficients of the electrolytes D were calculated using Eq. [2]. …”

Section: Permeability Coefficient Measurementmentioning

confidence: 95%

“…The concentration of KCl electrolyte solution on the left side of the cell (C 0 ) was kept constant at 10 03 mol/liter, while C d on the [2] right side of the cell was changed from 10 04 to 10 01 mol/ liter. The membrane area was 3.3 cm 2 , the volume of each cell was about 300 cm 3 , and the solutions in the cells were 3.5.…”

Section: Permeability Coefficient Of Electrolytementioning

confidence: 99%

Interfacial State Change of Cellulose Triacetate Membrane by Adsorption of Polyelectrolyte

Murata

Tanioka

1997

Journal of Colloid and Interface Science

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“…It is well known that the surface of the MPC polymers mildly interacts with blood components 9–14. Immobilizing the MPC polymer on the membrane surface by various methods has been reported 15–19. Surface modification of the cellulose hemodialysis membrane provides blood compatibility, that is, inhibition of clot formation and suppression of complement activation.…”

Section: Introductionmentioning

confidence: 99%

Preparation of blood‐compatible hollow fibers from a polymer alloy composed of polysulfone and 2‐methacryloyloxyethyl phosphorylcholine polymer

Hasegawa

Iwasaki

Ishihara

2002

J. Biomed. Mater. Res.

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Blood-compatible hollow fibers were successfully prepared from a polymer alloy composed of polysulfone (PSf) and the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer. To improve the hydrophilicity, fouling-resistance characteristics, and blood compatibility of the PSf hollow fiber in a hemodialyzer, an MPC polymer that can be blended with PSf was synthesized in order to prepare the polymer alloy (PSf/MPC polymer). The contents of the MPC polymer blended in the PSf were 7 and 15 wt%. The PSf/MPC polymer hollow fiber could be prepared by both wet and dry-wet processing methods. The hollow fiber took an asymmetric structure, that is, the hollow-fiber membrane had a dense skin layer on the porous sponge-like structure. The mechanical strength was higher than that of conventional PSf hollow fibers for hemodialysis. The surface characterization of the PSf/MPC polymer hollow fiber by x-ray photoelectron spectroscopy revealed that the MPC units were concentrated at the surface. The permeability for solutes through the PSf/MPC polymer hollow fibers was measured for 4 h. The permeabilities of both a low-molecular-weight compound and protein were greater than those of the PSf hollow fibers. The amount of adsorbed protein was lower on the PSf/MPC polymer hollow fiber when compared to that of the PSf hollow fiber. Moreover, platelet adhesion was also effectively inhibited on the PSf/MPC polymer hollow fiber. Based on these results, the addition of the MPC polymer to the PSf is a very useful method to improve the functions and blood compatibility of the hollow fiber.

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Protein adsorption resistible membrane for biosensor composed of polymer with phospholipid polar group

Cited by 19 publications

References 4 publications

Hemocompatible Cellulose Dialysis Membranes Modified with Phospholipid Polymers

Hemocompatible Cellulose Dialysis Membranes Modified with Phospholipid Polymers

Interfacial State Change of Cellulose Triacetate Membrane by Adsorption of Polyelectrolyte

Preparation of blood‐compatible hollow fibers from a polymer alloy composed of polysulfone and 2‐methacryloyloxyethyl phosphorylcholine polymer

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