Protein Adsorption Property of a Biomimetic Apatite Coating

Wen, Hao; Hippensteel, Elizabeth; Li, Pan Jian

doi:10.4028/0-87849-961-x.403

Cited by 2 publications

(2 citation statements)

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“…Although some proteins can bind calcium when dissolved, it is also possible that their adsorption on specific apatite faces will inhibit or direct apatite growth. 116 Apatite mineralization in vitro is increasingly inhibited with an increasing concentration of serum solution, most likely because the adsorbed proteins block further growth [117][118][119] but can also lead to differences in morphology of crystal coatings after mineral growth on a variety of calcium phosphates. 120 Human serum albumin has been pointed out as an important factor in this process, 118 but also the biopolymers that bind to different sites on apatite are more effective together at inhibiting apatite growth.…”

Section: Concentration Of Proteinmentioning

confidence: 99%

Proteins and Their Peptide Motifs in Acellular Apatite Mineralization of Scaffolds for Tissue Engineering

Benesch

Mano

Reis

2008

Tissue Engineering Part B: Reviews

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Many proteins in the inorganic=organic matrix of bone induce or modulate or inhibit mineralization of apatite in vivo. Many attempts have been made to mimic and understand this mechanism as part of bone formation, and ectopic mineralization and control thereof. Many attempts have also been made to use such proteins or protein fragments to harness their potential for improved mineralization. Such proteins and peptide motifs have also been the inspiration for attempts of making mimics of their structures and motifs using chemical or biological synthesis. The aim of this review is to highlight how proteins and (poly)peptides themselves impact mineralization in the human body, and how those could be used and have been used for improving apatite mineralization, for example, on or in materials that by themselves do not induce apatite mineralization but otherwise have interesting properties for use as bone tissue engineering scaffolds.

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Section: Concentration Of Proteinmentioning

confidence: 99%

Proteins and Their Peptide Motifs in Acellular Apatite Mineralization of Scaffolds for Tissue Engineering

Benesch

Mano

Reis

2008

Tissue Engineering Part B: Reviews

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“…Moreover, it is considered that since bone-like apatite prepared by the biomimetic process has porous surface structure, it has high affinity with cells and protein. It has been reported that bone-like apatite prepared by the biomimetic process has high protein adsorption ability [2].…”

Section: Introductionmentioning

confidence: 99%