Protein adsorption at the interface between charged polymer substrata and migrating osteoblasts

Shelton, Richard M.; Rasmussen, A.C.; Davies, John E.

doi:10.1016/0142-9612(88)90065-8

Cited by 141 publications

(89 citation statements)

References 7 publications

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“…15 In this study, inflammatory infiltrate and edema events were expressive and intense. No significant difference among the cements was observed on the 7 th day in regard to these events, and the events became gradually less intense and similar in subsequent periods, as a response to the presence of metal ions, [8][9]20 such as those of the aluminum present in all the cements used in this study. These ions are released in the tissue as a result of the presence and/or concentration of the different acids composing the GICs, such as polyalkenoic acids 19,9 and benzoic acid.…”

Section: Discussionmentioning

confidence: 98%

“…16 Nevertheless, for a cement to be adequate for clinical use, its components must be biocompatible. 15,[17][18][19][20][21] In this context, the aim of the present experiment was to show evidence of the action of different dental ionomers on tissues, by means of histological analysis. This analysis must fundamentally be based on how live vascularized tissue is influenced by aggression, which may be associated with cell death and necrosis, and how this aggression influences the developmental characteristics of capsule collagenization, inflammatory infiltrate and macrophage action.…”

Section: Discussionmentioning

confidence: 99%

“…15,22 In addition to the inflammatory infiltrate, circulatory alterations (edema) and multinucleated giant cells proved expressively greater with the Meron cement at 7 days, contrary to the respective results observed for the other cements. This was a proportional response of the body to the presence of aluminum and/or iron ions, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] whereby giant cells are released in the tissue to promote phagocytosis, a process by which the ions are surrounded and contained. Moreover, leachable substances from the GICs may also affect the epithelial cell rate of progression through the cellular cycle.…”

Section: Discussionmentioning

confidence: 99%

“…7 These acids have been pointed out as being substances capable of causing oxidative stress within the cells and interfering in cellular response. 19 Moreover, the low pH of these materials, especially when recently prepared, may have an influence on the potential inflammatory response, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] as supported by Ribeiro et al 7 These authors demonstrated that Ketac Cem cement powder did not induce alteration in cell DNA, whereas measurable genotoxicity was found for Ketac Cem liquid, composed of tartaric and benzoic acid, in all the dilutions tested in cell cultures.…”

Section: Discussionmentioning

confidence: 99%

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Histological analysis of biocompatibility of ionomer cements with an acid-base reaction

et al. 2014

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histological analysis of biocompatibility of ionomer cements with an acid-base reaction abstract: The purpose of this study was to evaluate the inflammatory and cure events of acid-based reactions using glass ionomer cement used for cementation of crowns, bridges, onlays and orthodontic bands implanted in subcutaneous tissue, at different time intervals. A total of 48 male Wistar rats were used, distributed into 4 groups (n = 12), as follows: Group C (control, polyethylene), Group ME (Meron), Group KC (Ketac Cem) and Group PR (Precedent). The animals were sacrificed after time intervals of 7, 15 and 30 days, and their tissues were analyzed under an optical microscope for such events as inflammatory infiltrate, edema, necrosis, granulation tissue, multinucleated giant cells, young fibroblasts and collagen. The results was assessed using Kruskal-Wallis and Dunn's tests (p < 0.05). In the initial period, intense inflammatory infiltrate was observed for all the materials with no significant difference among them (p = 0.104). Groups PR and KC showed significant difference in relation to Group C, at 7 days (p = 0.025) and 15 days (p = 0.006). Edema and giant cells were more expressive in Group ME, differing significantly from Groups C (p = 0.023) and KC (p = 0.039), respectively, at 7 days. Group ME showed a statistically significant difference in relation to Groups PR and KC for the presence of young fibroblasts (p = 0.009) and for collagen (p = 0.002), at 7 days. Within the limits of this in vivo study, Precedent and Ketac Cem glass ionomer cements showed better tissue healing with a greater number of fibroblasts and collagen, as compared to Meron.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Histological analysis of biocompatibility of ionomer cements with an acid-base reaction

et al. 2014

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“…It was reported that the interaction between a biomaterial and MG-63 cells depends on the topography [49][50][51][52][53], wettability [53,54] and surface energy and charge [55,56] of the biomaterial surface. We assumed that the cell adhesion was suppressed by the surface structure of HAp-coated HNS during the initial stage of the culture.…”

Section: Mg-63 Cell Culture On Cap-coated Hnsmentioning

confidence: 99%

Preparation and biological evaluation of hydroxyapatite-coated nickel-free high-nitrogen stainless steel

Sasaki

Inoue

Katada

et al. 2012

Science and Technology of Advanced Materials

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Calcium phosphate was formed on nickel-free high-nitrogen stainless steel (HNS) by chemical solution deposition. The calcium phosphate deposition was enhanced by glutamic acid covalently immobilized on the surface of HNS with trisuccinimidyl citrate as a linker. X-ray diffraction patterns and Fourier transform infrared spectra showed that the material deposited on glutamic acid-immobilized HNS within 24 h was low-crystallinity calcium-deficient carbonate-containing hydroxyapatite (HAp). The biological activity of the resulting HAp-coated HNS was investigated by using a human osteoblast-like MG-63 cell culture. The HAp-coated HNS stimulated the alkaline-phosphate activity of the MG-63 culture after 7 days. Therefore, HAp-coated HNS is suitable for orthopedic devices and soft tissue adhesion materials.

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Human monocyte morphology is affected by local substrate charge heterogeneity

Kapur

Lilien

Picciolo

et al. 1996

J. Biomed. Mater. Res.

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Cells are sensitive to topological, chemical, and electrical properties of substrates on which they are grown. However, most studies of cell-surface interactions have neglected electrical effects or confounded them with other substrate properties. The use of nanofabrication technology has made it possible to fabricate optically transparent surfaces with controlled chemistry and topology, and with active, controllable surface charge density in domains as small as 1-4 microns. Human monocytes incubated on polystyrene with 3.3 microns-wide strip domains, alternately charged so as to maintain overall charge neutrality, show significant charge density and time-dependent increases (greater than twofold) in cell area and cell perimeter after challenge with a phagocytic trigger (human IgG opsonized zymosan particles). Additional utlrastructural studies on silicon dioxide substrates show charge-density-dependent qualitative morphological differences. These studies clearly demonstrate that human monocytes respond in vitro to local surface-charge heterogeneity in the absence of substrate topology and compositional variation.

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Protein adsorption at the interface between charged polymer substrata and migrating osteoblasts

Cited by 141 publications

References 7 publications

Histological analysis of biocompatibility of ionomer cements with an acid-base reaction

Histological analysis of biocompatibility of ionomer cements with an acid-base reaction

Preparation and biological evaluation of hydroxyapatite-coated nickel-free high-nitrogen stainless steel

Human monocyte morphology is affected by local substrate charge heterogeneity

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