Protein A immunoadsorption combination with immunosuppressive therapy improves neuropsychiatric systemic lupus erythematosus: A case report

Wen, Feng; Wu, Xiaoling; Liao, Ruyi; Feng, Zhonglin; Li, Zhilian; Fu, Xinping; Fu, Lei; Li, Sijia; Li, Zhuo; Sheng, Li; Wang, Wenjian; Huang, Biao; He, Chaosheng; Shi, Wei; Liang, Xinling; Liu, Shuangxin

doi:10.1002/ccr3.3140

Cited by 2 publications

(1 citation statement)

References 18 publications

(35 reference statements)

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“…At present, the treatment of rheumatism mainly uses hormones and immunosuppressants, but the above drugs have great side effects and take a long time to take effect, which has limitations for critical patients. In recent years, a new therapy to remove specific autoimmune components in the immune system: immunoadsorption (IA) has become a hot research direction in the treatment of autoimmune diseases [2]. It is a more targeted approach to the treatment of rheumatic immune diseases.…”

Section: Introductionmentioning

confidence: 99%

Application of Clinical Nursing Pathway in the Peri-Treatment Period of Immunoadsorption Therapy for Rheumatic Immune Diseases

Li¹,

Fan²,

Ren³

2023

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Objective: The paper aims to investigate the clinical nursing pathway (CNP) in the application of immunosorption therapy in patients with rheumatic immune disease. Methods: Convenience sampling method was used to select inpatients who received immunoadsorption therapy from January 2020 to December 2022 in the rheumatology and Immunology department of a 3A hospital in Jingzhou City. 30 patients from January 2020 to June 2021 were selected as control group, and 30 patients from July 2021 to December 2022 were selected as observation group. The control group was given routine nursing. On the basis of the control group, the observation group used a clinical nursing pathway for intervention during the perioperative period of immunosorbent therapy. The incidence of adverse reactions, patient satisfaction, and nurse satisfaction during immunosorbent therapy between the control group and the observation group were compared. Results: After intervention, the incidence of adverse reactions in the observation group was significantly lower than that in the control group, while patient satisfaction and nurse satisfaction in the observation group were significantly higher than those in the control group. The results are all statistically significant (P < 0.05). Conclusion: Clinical nursing pathway is beneficial to reduce the incidence of adverse reactions in patients with immunoadsorption during peri-treatment and improve the satisfaction of patients and nurses.

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Section: Introductionmentioning

confidence: 99%

Application of Clinical Nursing Pathway in the Peri-Treatment Period of Immunoadsorption Therapy for Rheumatic Immune Diseases

Li¹,

Fan²,

Ren³

2023

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Neuropsychiatric Systemic Lupus Erythematosus: A Remaining Challenge

Mrak

Bonelli

Radner

2022

CPD

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Systemic Lupus Erythematosus (SLE) is an autoimmune disease, which affects a wide range of organs with variable clinical features. Involvement of the nervous system is a challenging and multifaceted manifestation of the disease, presenting with a broad range of symptoms. Neuropsychiatric lupus (NPSLE) encompasses seven syndromes of the peripheral and 12 of the central nervous system, associated with a high disease burden. Despite advances in the management of SLE, NP manifestations still pose a challenge to clinicians. First, diagnosis and attribution to SLE is difficult due to the lack of specific biomarkers or imaging modalities. Second, therapeutic options are limited, and evidence is mainly based on case reports and expert consensus, as clinical trials are sparse. Moreover, no validated outcome measure on disease activity exists. Current recommendations for treatment include supportive as well as immunosuppressive medication, depending on the type and severity of manifestations. As NPSLE manifestations are increasingly recognized, a broader spectrum of therapeutic options can be expected.

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Protein A immunoadsorption combination with immunosuppressive therapy improves neuropsychiatric systemic lupus erythematosus: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 18 publications

Application of Clinical Nursing Pathway in the Peri-Treatment Period of Immunoadsorption Therapy for Rheumatic Immune Diseases

Application of Clinical Nursing Pathway in the Peri-Treatment Period of Immunoadsorption Therapy for Rheumatic Immune Diseases

Neuropsychiatric Systemic Lupus Erythematosus: A Remaining Challenge

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