Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats

Wu, Lidong; Qiao, Hong; Li, Y.; Li, L.

doi:10.1016/j.phymed.2007.07.060

Cited by 134 publications

(89 citation statements)

References 15 publications

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“…[25][26][27][28] Furthermore, it has been shown to have clinical applications in the treatment of coronary heart disease and diabetic nephropathy. [29][30][31] The previous study found that Puerarin may induce therapeutic angiogenesis in myocardium by inducing VEGF and eNOS expression in myocardium of rat with myocardial infarction. 32,33 It would scavenge free radicals, lower serum cholesterol, and have antithrombotic and antiallergic activities.…”

Section: Discussionmentioning

confidence: 99%

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Zhang

Wang

et al. 2015

Renal Failure

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Diabetic nephropathy (DN) is a serious complication and it leads to kidney failure. The endothelial nitric oxide synthases (eNOS) seems to be involved in the development and progression of DN. The Puerarin is a well-known Chinese traditional formula, which is widely used in clinical practice for the treatment of kidney disease. The present study was designed to investigate the renal protective effects of Puerarin on streptozotocin (STZ)-induced diabetic rats. Thirty Sprague-Dawley (SD) male rats were divided into three groups at random. The diabetic group and the Puerarin-treated group were intraperitoneally injected with STZ 65 mg/kg and the Puerarin-treated rats were intraperitoneally injected Puerarin 100 mg/kg/day for 4 weeks. The results showed the Puerarin could improve body weight, blood sugar, BUN and SCr levels, and reduce ultrastructural changes of kidney in diabetic rats. It also attenuated eNOS expression in glomerular endothelial cells and tubular cells of diabetic rats with Puerarin treatment (p50.05). The Puerarin had significant renal-protective effects for the diabetic nephropathy, possibly through regulating eNOS expression, and it may be used as a potential therapeutic reagent.

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Section: Discussionmentioning

confidence: 99%

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Zhang

Wang

et al. 2015

Renal Failure

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“…Recently, it was found puerarin, extracted from pueraria, is antioxidative, antithrombotic, and decreases cell injuries secondary to lipid peroxidation by protecting the stability of the cell membrane [4,6,7,11,12,53,55]. The findings indicate puerarin may have the potential to prevent alcohol-induced ON.…”

Section: Introductionmentioning

confidence: 98%

Preventive Effects of Puerarin on Alcohol-induced Osteonecrosis

Wang

Yin

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Alcohol can induce adipogenesis by bone marrow stromal cells and may cause osteonecrosis of the femoral head. Currently, there are no medications available to prevent alcohol-induced osteonecrosis. We hypothesized puerarin, a Chinese herbal medicine with antioxidative and antithrombotic effects, can prevent alcohol-induced adipogenesis and osteonecrosis. Both bone marrow stromal cells (in vitro) and mice (in vivo) were treated either with ethanol or with ethanol and puerarin, with an untreated group serving as a control. In the in vitro study, the number of adipocytes, contents of triglycerides, and levels of PPARc mRNA expression were decreased and alkaline phosphatase activity, contents of osteocalcin, and levels of osteocalcin mRNA expression were increased in cells treated with both alcohol and puerarin, compared with cells treated with alcohol only. In the in vivo study, marrow necrosis, fat cell hypertrophy and proliferation, thinner and sparse trabeculae, diminished hematopoiesis, and increased empty osteocyte lacunae in the subchondral region of the femoral head were observed in mice treated with alcohol. However, no such changes were seen in femoral heads of mice treated with alcohol and puerarin. The data suggest puerarin can inhibit adipogenic differentiation by bone marrow stromal cells both in vitro and in vivo and prevents alcohol-induced osteonecrosis in this model.

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“…Puerarin, an isoflavone glycoside, is extracted from the root of the traditional Chinese medicines Pueraria lobata (Willd), Ohwi, and Pueraria thomsonni Benth. 20 Its comprehensive biographical actions have been well-documented by numerous studies, regarding the therapeutic effects on coronary heart disease, 21 cardiac infarction, 22 angina pectoris, hypertension, 23 hypercholesterolemia, 24,25 hemicranias, as well as diabetic retinopathy. 26 However, puerarin is a poorly water-soluble drug with low bioavailability upon oral administration.…”

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confidence: 99%

Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach

Tang¹,

Hu²,

Liao³

et al. 2013

IJN

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The purpose of the present work was to determine the mechanisms by which microemulsions (MEs) enhance the oral bioavailability of puerarin. The in situ perfusion method was used in rats to study the absorption mechanisms of an oil-in-water (O/W) microemulsion (O/W-ME) and a water-in-oil (W/O) microemulsion (W/O-ME). The possibility of lymphatic transport of the MEs was investigated using a chylomicron flow blocking approach. The results for the absorption mechanisms in the stomach and intestines indicated that the absorption characteristics of the O/W-ME and W/O-ME depend on the segment. The W/O-ME had higher internal membrane permeability than the O/W-ME. The results of the lymphatic transport analyses showed that both the O/W-ME and W/O-ME underwent lymphatic transport and that this pathway was a major contributor to the oral bioavailability of MEs. Furthermore, the type of ME can significantly affect the absorption of puerarin through the lymphatic system due to the oil content and the form of the microemulsion after oral administration. In conclusion, these data indicate that microemulsions are an effective and promising delivery system to enhance the oral bioavailability of poorly water-soluble drugs.

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Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats

Cited by 134 publications

References 15 publications

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression

Preventive Effects of Puerarin on Alcohol-induced Osteonecrosis

Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach

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