Protective roles of Cordyceps on lung fibrosis in cellular and rat models

Chen, Mengli; Cheung, Fanny M.; Chan, Ming Hung; Hui, Pui Wah; Ip, Siu‐Po; Ling, Yick Hin; Tao, Chun; Liu, Wing Keung

doi:10.1016/j.jep.2012.06.033

Cited by 42 publications

(27 citation statements)

References 33 publications

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“…13,14 In addition, cordycepin can activate AMPKα and inhibit oxidative stress. [15][16][17] However, no research has been performed to elucidate the effect of cordycepin on cardiac hypertrophy. The purpose of this study was to determine whether cordycepin can attenuate cardiac hypertrophy, induced by 1 μmol/L Ang II in cultured neonatal rat cardiac myocytes in vitro and by pressure overload in mice.…”

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confidence: 99%

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway

Wang

Duan

et al. 2019

J Cellular Molecular Medi

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Increase of myocardial oxidative stress is closely related to the occurrence and development of cardiac hypertrophy. Cordycepin, also known as 3'‐deoxyadenosine, is a natural bioactive substance extracted from Cordyceps militaris (which is widely cultivated for commercial use in functional foods and medicine). Since cordycepin suppresses oxidative stress both in vitro and in vivo, we hypothesized that cordycepin would inhibit cardiac hypertrophy by blocking oxidative stress‐dependent related signalling. In our study, a mouse model of cardiac hypertrophy was induced by aortic banding (AB) surgery. Mice were intraperitoneally injected with cordycepin (20 mg/kg/d) or the same volume of vehicle 3 days after‐surgery for 4 weeks. Our data demonstrated that cordycepin prevented cardiac hypertrophy induced by AB, as assessed by haemodynamic parameters analysis and echocardiographic, histological and molecular analyses. Oxidative stress was estimated by detecting superoxide generation, superoxide dismutase (SOD) activity and malondialdehyde levels, and by detecting the protein levels of gp91 phox and SOD. Mechanistically, we found that cordycepin activated activated protein kinase α (AMPKα) signalling and attenuated oxidative stress both in vivo in cordycepin‐treated mice and in vitro in cordycepin treated cardiomyocytes. Taken together, the results suggest that cordycepin protects against post‐AB cardiac hypertrophy through activation of the AMPKα pathway, which subsequently attenuates oxidative stress.

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confidence: 99%

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway

Wang

Duan

et al. 2019

J Cellular Molecular Medi

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“…O. sinensis also has obvious therapeutic and health care effects on other organ systems and diseases, such as antimicrobial activities (Mamta et al ., ), protection of lung (Chen et al ., ) and liver (Wang et al ., ) functions, therapeutic effects on diabetes (El Ashry et al ., ; Liu et al ., ) and asthma (Kuo et al ., ). Studies also found that O .…”

Section: Functional Activities and Mechanisms Of O Sinensismentioning

confidence: 99%

“…Other therapeutic and health care potentialities O. sinensis also has obvious therapeutic and health care effects on other organ systems and diseases, such as antimicrobial activities (Mamta et al, 2015), protection of lung (Chen et al, 2012) and liver (Wang et al, 2012a) functions, therapeutic effects on diabetes (El Ashry et al, 2012;Liu et al, 2016) and asthma (Kuo et al, 2001). Studies also found that O. sinensis can increase hypoxia tolerance (Singh et al, 2013) and ATP levels on muscle strength, power output and endurance (Chen et al, 2014a;Kumar et al, 2011).…”

Section: Prevention Of Osteoporosismentioning

confidence: 99%

The Mechanisms of Pharmacological Activities ofOphiocordyceps sinensisFungi

Huang

Chen

et al. 2016

Phytother. Res.

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The entomopathogenic fungus Ophiocordyceps sinensis, formerly known as Cordyceps sinensis, has long been used as a traditional Chinese medicine for the treatment of many illnesses. In recent years its usage has increased dramatically because of the improvement of people's living standard and the emphasis on health. Such demands have resulted in over-harvesting of this fungus in the wild. Fortunately, scientists have demonstrated that artificially cultured and fermented mycelial products of O. sinensis have similar pharmacological activities to wild O. sinensis. The availability of laboratory cultures will likely to further expand its usage for the treatment of various illnesses. In this review, we summarize recent results on the pharmacological activities of the components of O. sinensis and their putative mechanisms of actions. Copyright © 2016 John Wiley & Sons, Ltd.

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“…However, most studies on Cordyceps are animal studies, in vitro studies, or ex vivo studies, and conclusions on the efficacy of Cordyceps are difficult to make 22 – 24 . A systematic review on the efficacy of Cordyceps in treating chronic kidney disease found no definite conclusion due to the poor quality of evidence 20 .…”

Section: Cordycepsmentioning

confidence: 99%