“…[3,14] Additionally, N-acetylcysteine, α-tocopherol, and melatonin administered to rats following I/R decrease the ROS levels providing kidney damage protection. [2,3,[13][14][15] Several experimental studies suggest that antioxidant vitamins, including ascorbic acid (AA), produce cytoprotective effects due to reduction of ROS. [16] Thus, AA is a very powerful antioxidant agent.…”