Protective role of α-tocopherol and caffeic acid phenethyl ester on ischemia–reperfusion injury via nitric oxide and myeloperoxidase in rat kidneys

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

“…Previous experiments show that various exogenous antioxidant agents such as allopurinol, melatonin, tocopherol, leflunomide, and some flavonoids have the potential to reduce I/R induced-renal injury and help the improvement of kidney function. [10,[13][14][15]26] In this study, we used AA as an exogenous antioxidant. AA is one of the water-soluble vitamins and is well known as a strong antioxidant agent.…”

“…[3,14] Additionally, N-acetylcysteine, α-tocopherol, and melatonin administered to rats following I/R decrease the ROS levels providing kidney damage protection. [2,3,[13][14][15] Several experimental studies suggest that antioxidant vitamins, including ascorbic acid (AA), produce cytoprotective effects due to reduction of ROS. [16] Thus, AA is a very powerful antioxidant agent.…”

The Effect of Antioxidant Caffeic Acid Phenethyl Ester (Cape) on Some Enzyme Activities in Cisplatin-Induced Neurotoxicity in Rats

“…The agents that can downregulate the activation of NF-κB have potential for therapeutic interventions. CAPE has been shown to block specifically and completely the activation of NF-κB induced by a wide variety of inflamatory agents including tumor necrosis factor and H 2 O 2 (46).…”

Phenylpropanoids in radioregulation: double edged sword

“…A protective role for CAPE (2) in oxidative status through its free radical scavenging and antioxidant activities has been proposed (Calikoglu et al, 2003;Gurel et al, 2004). An investigation using lung tissues of Wistar albino rats revealed that the activities of antioxidant enzymes including catalase (CAT) and superoxide dismutase (SOD) were decreased in the radiation only group compared with the saline (control) and radiation with CAPE (2) groups, indicating that CAPE (2) treatment with radiation therapy attenuated radiationinduced pulmonary injury in vivo, possibly by its antioxidant effect (Yildiz et al, 2008).…”