Protective role of turmeric against deltamethrin induced renal oxidative damage in rats

Shivanoor, Shiddappa Mallappa; David, Muniswamy

doi:10.1016/j.bionut.2014.08.007

Cited by 9 publications

(4 citation statements)

References 72 publications

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“…To date, different techniques have been employed to diagnose infertility in males, among them the use of vibration spectroscopy is a new technique in the field of reproductive medicine [47] . This technique has been utilized well in biophysical and biochemical research for both quantitative and qualitative analysis of biomolecules such as proteins, lipids, carbohydrates and nucleic acids [48] . In addition to this, FT-IR spectrum provides sensitive ‘fingerprint’ for the oxidative damage to the different biomolecules present in the sperm [47] .…”

Section: Introductionmentioning

confidence: 99%

Fourier transform infrared (FT-IR) study on cyanide induced biochemical and structural changes in rat sperm

Shivanoor

David

2015

Toxicology Reports

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Section: Introductionmentioning

confidence: 99%

Fourier transform infrared (FT-IR) study on cyanide induced biochemical and structural changes in rat sperm

Shivanoor

David

2015

Toxicology Reports

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“…The present study also observed the same toxicity in CYP-treated groups. According to Shivanoor and David, 36 deltamethrin intoxication caused tubular dilatation of proximal tubules, inflammation, infiltration, and tubular cell desquamation necrosis. Raj et al 37 suggested that medullary congestion in the kidney was observed when mice were orally treated with a combination of cypermethrin and endosulfan.…”

Section: Discussionmentioning

confidence: 99%

Systematic Toxicity of Cypermethrin and Alterations in Behavior of Albino Rats

et al. 2023

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The present study aimed to evaluate the effect of repeatedly orally administering cypermethrin (CYP) at different doses on the behavior, hematology, and histology of adult male and female albino rats for 1 month. For this, animals have divided into four different groups and each group contained 10 animals (5 males and 5 females). Group I served as a control group and groups II, III, and IV were represented as experimental groups and treated with CYP at doses of 25, 50, and 75 mg/kg body weight/ day/rat, respectively. Through the behavioral results of this study, it was observed that cypermethrin intoxication causes dosedependent moderate to high toxicity symptoms like vomiting, decreased food consumption, thick eye discharge, rolling, tremors, loss of coordination, tilted neck, and convulsion attacks. A significant reduction in body weight of high-dose (75 mg)-treated animals, especially in females, was noticed. Similarly, hematological data also revealed that CYP exposure caused a reduction in the level of Hb, RBC, WBC, neutrophil, and other blood indices such as PCV and MCV and an increase in the lymphocyte percentage in both male and female experimental groups. Microscopic observation stated that CYP produced infiltration of cells near the central vein, hepatocyte degeneration, congestion of the central and portal veins, hemorrhage, and necrosis in liver tissue. Shrinkage of the glomerulus, necrosis in the glomerulus and renal tubules, congestion of blood cells, and hemorrhage were seen in kidney tissue. The current study suggests that hepatotoxicity and nephrotoxicity due to cypermethrin exposure were more prominent in female rats.

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“…The present results are in parallel with that found by many other researchers, where deltamethrin was found to induce severe histopathological alterations in rats (El-Gerbed, 2014; Sharma et al, 2014), common carp (Arslan et al, 2017; Dawood et al, 2020; Wu et al, 2022), and quail (Yang et al, 2022). These alterations included hemorrhage, necrosis, mass degeneration of interlamellar cells, and pyknosis (Fadina and Fayinminnu, 2016; Issam et al, 2009; Kumar and Nagar, 2014; Maria De Oliveira et al, 2021; Pullanna and Philip, 2014; Shivanoor and David, 2014; Wu et al, 2022). Therefore, the histological changes observed in the present study can be used as indicators of alterations in the biochemical components in tissue.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Elbanna,

Osman,

Salama

2023

Toxicol Ind Health

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Deltamethrin is one of the most effective pyrethroid compounds, widely employed in veterinary medicine, public health, and farming. Deltamethrin-triggered oxidative stress largely causes serious harm to an organism. Acute toxicity of this compound was extensively investigated, while less information is available on its oral sub-acute effects. This study assessed, in the male Albino rats, the effects of oral gavage of either 0.874 mg/kg (0.01 LD50) or 8.740 mg/kg (0.10 LD50) of deltamethrin for successive 14 days to investigate its effects on biomarkers and to detect the tissue injury in rats following subacute deltamethrin treatment. It was found that levels of glutathione peroxidase, superoxide dismutase, and catalase in the brain, kidney, and liver, alkaline phosphatase (ALP), and uric acid in serum, hematocrit, mean corpuscular volume (MCV), white blood cells (WBC)s, eosinophils, and basophils were significantly reduced compared with untreated rats. However, when rats were treated with deltamethrin for successive 14 days, alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities in serum and the levels of thiobarbituric acid reactive substances (TBARs) in brain, kidney, and liver, red blood cell distribution width (RDW-CV), total protein, monocytes, and basophils and the ratios of neutrophils to lymphocytes, an aggregated marker of systemic inflammation and systemic immune inflammation indexes, significantly increased compared with the control group. Histologic lesions were observed in the liver, kidney, brain, testis, and epidemies in rats exposed to subacute deltamethrin for 14 days, and most tissues of rats treated with 0.10 LD50 of deltamethrin were more affected than those treated with 0.01 LD50. These findings strongly suggest that subacute exposure to deltamethrin caused significant systemic toxicity through oxidative stress resulting in biochemical and histological changes in the studied tissues. These findings highlight the potential harmful effects of deltamethrin and emphasize the importance of understanding the subacute effects of this compound, particularly in the context of veterinary medicine, public health, and farming.

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Protective role of turmeric against deltamethrin induced renal oxidative damage in rats

Cited by 9 publications

References 72 publications

Fourier transform infrared (FT-IR) study on cyanide induced biochemical and structural changes in rat sperm

Fourier transform infrared (FT-IR) study on cyanide induced biochemical and structural changes in rat sperm

Systematic Toxicity of Cypermethrin and Alterations in Behavior of Albino Rats

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

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