Protective role of the aqueous extract of Brassica nigra seed against cadmium chloride toxicity in lung tissue and hematological parameters of female rats

Asaad, Nahla Kamal; Razooqi, Qasim Azeez

doi:10.1016/j.matpr.2021.12.003

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…As stated in the Introduction, Cd as a pollutant is closely associated with the occurrence of lung cancer and its related diseases (Cao et al, 2021;Lener et al, 2021). Am et al (2022) (Nka & Qar, 2021). Vanillin was found able to relieve CdCl 2caused lung damage by attenuating inflammation and lung barrier dysfunction (Liu et al, 2021).…”

Section: Discussionmentioning

confidence: 96%

“…Furthermore, previous studies reported that biologically active compounds could protect against Cd‐induced lung damage. Aqueous extract of Brassica nigra seed was found to mitigate CdCl 2 ‐caused lung damage in rats through inducing oxidative stress conditions (Nka & Qar, 2021). Vanillin was found able to relieve CdCl 2 ‐caused lung damage by attenuating inflammation and lung barrier dysfunction (Liu et al., 2021).…”

Section: Discussionmentioning

confidence: 99%

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The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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Cadmium (Cd) is a heavy metal toxic that can cause health problems including lung injury. This study was set out to meet the growing demand for effective treatment of lung diseases and explore the mechanism of caffeic acid phenethyl ester (CAPE, a natural phenolic acid) protect against Cd‐caused lung damage. In this study, CAPE significantly increased mice body weight, decreased lung W/D ratio, and alleviated histomorphological injury. CAPE mitigated CdCl2‐induced oxidative stress through Nrf2/HO‐1/NQO1 pathway, suppressed inflammation via MyD88/NF‐κB pathway, and alleviated apoptosis by modulating apoptosis mediators. CAPE also inhibited the CdCl2‐caused decreasing of TLR4 level and the increasing of miR‐182‐5p level, which is achieved by miR‐182‐5p sponging TLR4. Collectively, miR‐182‐5p is involved in CAPE against CdCl2‐caused lung damage by targeting TLR4. MiR‐182‐5p/TLR4 is a new pathway for inhibiting oxidative stress, apoptosis, and inflammation in CAPE‐mediated lung protection, which provides a novel avenue for treatment therapies.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Hao

Zhou

et al. 2023

Food Frontiers

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“…An experimental study on Brassica nigra seeds revealed their protective potential against the toxic effects of cadmium chloride (CdCl2) in female albino rats [40]. Treatment with the aqueous extract of the seeds restored normal blood parameters and mitigated lung tissue damage induced by cadmium chloride, suggesting protective effects against oxidative stress and tissue damage caused by toxic substances .…”

Section: Protective Effects Against Cadmium Chloride Toxicity On Lungsmentioning

confidence: 99%

Kanji Drink: The Tangy Carrot Beverage for Good Health

2024

Curr Res Cmpl Alt Med

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Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties

et al. 2022

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Traditionally, Brassica species are widely used in traditional medicine, human food, and animal feed. Recently, special attention has been dedicated to Brassica seeds as source of health-promoting phytochemicals. This review provides a summary of recent research on the Brassica seed phytochemistry, bioactivity, dietary importance, and toxicity by screening the major online scientific database sources and papers published in recent decades by Elsevier, Springer, and John Wiley. The search was conducted covering the period from January 1964 to July 2022. Phytochemically, polyphenols, glucosinolates, and their degradation products were the predominant secondary metabolites in seeds. Different extracts and their purified constituents from seeds of Brassica species have been found to possess a wide range of biological properties including antioxidant, anticancer, antimicrobial, anti-inflammatory, antidiabetic, and neuroprotective activities. These valuable functional properties of Brassica seeds are related to their richness in active compounds responsible for the prevention and treatment of various chronic diseases such as obesity, diabetes, cancer, and COVID-19. Currently, the potential properties of Brassica seeds and their components are the main focus of research, but their toxicity and health risks must also be accounted for.

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Protective role of the aqueous extract of Brassica nigra seed against cadmium chloride toxicity in lung tissue and hematological parameters of female rats

Cited by 3 publications

References 8 publications

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

The antagonistic effect of caffeic acid phenethyl ester on cadmium‐caused pulmonary toxicity: MiR‐182‐5p/TLR4 axis

Kanji Drink: The Tangy Carrot Beverage for Good Health

Brassica Genus Seeds: A Review on Phytochemical Screening and Pharmacological Properties

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