Protective role of supplement with foreign <i>Bifidobacterium</i> and <i>Lactobacillus</i> in experimental hepatic ischemia‐reperfusion injury

Xing, Huichun; Li, Lanjuan; Xu, Kaijin; Shen, Tian; Chen, Yunbo; Sheng, Jifang; Chen, Yu; Fu, Su-Zhen; Chen, Chunlei; Wang, Jianguo; Dong, Yan; Dai, Fangwei; Zheng, Shusen

doi:10.1111/j.1440-1746.2006.04306.x

Cited by 76 publications

(45 citation statements)

References 29 publications

(39 reference statements)

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“…The plasma endotoxin was determined using a chromogenic Limulus Amebocyte Lysate quantitative assay following the manufacturer's instructions (Eihua Medical, Shanghai, China) [11]. The detection limit of endotoxin was 0.20 units and expressed as nanograms per liter.…”

Section: Plasma Endotoxinmentioning

confidence: 99%

Structural Shifts of Fecal Microbial Communities in Rats with Acute Rejection after Liver Transplantation

Xie

Luo

et al. 2012

Microb Ecol

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Section: Plasma Endotoxinmentioning

confidence: 99%

Structural Shifts of Fecal Microbial Communities in Rats with Acute Rejection after Liver Transplantation

Xie

Luo

et al. 2012

Microb Ecol

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“…The enzymes activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in RMC were detected following instructions of the commercial kit (Nanjing Jiancheng Bioengineering Institute, Nanjing, China) [13. ]…”

Section: Methodsmentioning

confidence: 99%

HGF Protects Rat Mesangial Cells from High-Glucose-Mediated Oxidative Stress

Li¹,

Jiang²,

Lin³

et al. 2006

Am J Nephrol

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Background: Oxidative stress has been considered to be a common pathogenetic factor of diabetic nephropathy. Recent observations suggested that hepatocyte growth factor (HGF) was an antioxidant growth factor; thus, its renoprotective effects in diabetic nephropathy might be related to antioxidant mechanism. The aim of the present study was to evaluate whether HGF could prevent rat mesangial cells (RMC) from high-glucose-mediated oxidative stress and explore its relevant mechanism. Methods: RMC were cultured in 5.6 mM (NG) or 30 mM (HG) glucose in the absence or presence of HGF (20 ng/ml) and c-met inhibitor SU11274 (5 µM) for 24 h. Results: c-met expression in HG was markedly increased. Enhanced oxidative stress was observed in HG as evidenced by elevated reactive oxygen species and malondialdehyde levels and decreased glutathione level, which was markedly attenuated by HGF. HGF also inhibited HG-induced p22^phox and aldose reductase upregulation and prevented HG-reduced glutamate-cysteine ligase catalytic subunit (GCLC) expression through inhibiting USF binding to negative regulatory region of GCLC promoter. Reduced glucose-6-phosphate dehydrogenase activity and expression in RMC by HG was rescued by HGF. Conclusion: HGF could function as an antioxidant factor and protect against HG-mediated oxidative stress by enhancing ROS scavenging and suppressing ROS production.

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“…Relative liver weights of the live B. adolescentis SPM0212 treated group were even lower than those of normal control group, but the difference between them was not significant statistically. These results are not fully (Xing et al, 2006). However, to date, little work has been undertaken to explore the hepatoprotective activities of probiotics, and in fact, the molecular mechanisms involved remain to be elucidated.…”

Section: Discussionmentioning

confidence: 79%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

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Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

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Protective role of supplement with foreign Bifidobacterium and Lactobacillus in experimental hepatic ischemia‐reperfusion injury

Abstract: Bifidobacterium Catenulatum ZYB0401 in combination with Lactobacillus Fermentum ZYL0401 could be useful in restoring intestinal microflora and in preventing liver injury in hepatic I/R of rats.

Cited by 76 publications

References 29 publications

Structural Shifts of Fecal Microbial Communities in Rats with Acute Rejection after Liver Transplantation

Structural Shifts of Fecal Microbial Communities in Rats with Acute Rejection after Liver Transplantation

HGF Protects Rat Mesangial Cells from High-Glucose-Mediated Oxidative Stress

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

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