Protective role of Siberian onions against toxin-induced liver dysfunction: an insight into health-promoting effects

Jiang, Yuchen; Han, Xin; Dou, Jia-Yi; Yuan, Ming-Hui; Zhou, Mei-Jie; Cui, Zhenyu; Lian, Li-Hua; Nan, Ji‐Xing; Zhang, Xian; Wu, Yan-Ling

doi:10.1039/d1fo04404d

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…By decreasing oxidative stress, onion and apple supplementations may help preventing the proinflammatory activation observed in OC vessels. Interestingly, and in line with the present findings, Jiang et al (2022) [ 79 ] recently reported that Siberian onion reduced the positive expressions of α-smooth muscle actin and NLRP3 by inhibiting signal transducer and activator of transcription 3 phosphorylation in activated hepatic stellate cells. Moreover, a study by Guo et al (2013) [ 128 ] concluded that quercetin and quercetin-3- O -glucuronide inhibited ROS-associated inflammation by blocking IKKβ/NF-κB activation and effectively facilitated insulin signaling transduction along insulin receptor substrate-1/Akt/eNOS pathway in the endothelium.…”

Section: Resultssupporting

confidence: 91%

“…An early study shows that increased TIMP-1 levels are a risk factor for mortality among congestive heart failure patients [ 78 ]. Recently, Jiang et al (2022) [ 79 ] found that Siberian onions decreased serum transaminase levels and oxidative stress, and regulated the balance of the extracellular matrix in CCl4-induced mice, including α-smooth muscle actin (α-SMA), type I collagen, and TIMP-1, suggesting that Siberian onions reduced the release of inflammatory factors and regulated apoptosis-associated proteins, which is related to the inhibition of signal transducer and activator of transcription 3 (STAT3) phosphorylation. Additionally, considering that TIMP-1 is an inhibitor of MMP-1 in tissue and the amount of type I collagen is tightly regulated by balance between MMP-1 and TIMP-1, Cho et al (2010) [ 80 ] demonstrated that onion extract and quercetin play a role in the antifibrotic effect and promotion of wound healing in skin through up-regulation of MMP-1 expression.…”

Section: Resultsmentioning

confidence: 99%

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Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

et al. 2022

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The objective of this study was to investigate the effects of onion and apple functional ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard diet [obese control (OC) group], standard diet containing 10% onion [obese onion 10% (OO) group] and standard diet containing 10% apple [obese apple 10% (OA) group] for 8 weeks. Food intake and body weight gain were higher in obese than in lean rats. Food efficiency was lower in OO and AO groups compared with OC group. Within the obese groups, total cholesterol, LDL-cholesterol, triacylglycerols, glucose, insulin and triglyceride-glucose index were lower in OO group than in OC group, and HDL-cholesterol was higher in OO group than in OC group. In general, antioxidant activity (ABTS•+ and FRAP), antioxidant enzyme activities (CAT, SOD, GPx), GSH/GSSG ratio, nitrate/nitrite and GLP-1 increased in OO and OA groups compared with OC. Oxidative stress biomarkers, namely protein carbonyls, 8-hydroxy-2’-deoxyguanosine, 8-epi-prostaglandin F2α, inflammatory and vascular injury biomarkers (PAI-1, TIMP-1, VEGF, sICAM-1, sE-Selectin, MCP-1) and leptin, were lower in OO and OA groups than in OC group. Endothelial impairment was partially reversed, and superoxide content and gene expression of NLRP3, NFKβ1 and COX2 decreased, in OO and OA groups with respect to OC group. The study demonstrates that high pressure-processed onion and apple functional ingredients administration to obese Zucker rats causes beneficial effects on metabolic health, in particular through improving food efficiency ratio; exerting pronounced lipid-lowering effects; reducing glycemia, insulinemia, and biomarkers of hepatic injury (ALT, AST); improving antioxidant, oxidative stress, inflammatory and vascular injury biomarkers, metabolic hormones, and endothelial function; and decreasing proinflammatory gene expression of NLRP3, NFKβ1 and COX2.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

et al. 2022

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“…Liver fibrosis means that the increase of fibrous tissue in liver tissue was caused by inflammatory stimulation. On the other hand, the sustained inflammatory response exacerbates the degree and progression of liver fibrosis. , Our findings showed that RK had the potential to reduce the levels of inflammatory cytokines in mice induced with TAA or in activated HSCs. In particular, RK could modulate the inflammatory factors of activated HSCs cultured with the supernatant of LPS-primed THP-1.…”

Section: Resultsmentioning

confidence: 99%

Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling

Jiang,

Dou,

Xuan

et al. 2024

J. Agric. Food Chem.

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Hepatic fibrosis is a compensatory response to chronic liver injury and inflammation, and dietary intervention is recommended as one of the fundamental prevention strategies. Raspberry ketone (RK) is an aromatic compound first isolated from raspberry and widely used to prepare food flavors. The current study investigated the hepatoprotection and potential mechanism of RK against hepatic fibrosis. In vitro, hepatic stellate cell (HSC) activation was stimulated with TGF-β and cultured with RK, farnesoid X receptor (FXR), or peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) agonist or inhibitor, respectively. In vivo, C57BL/6 mice were injected intraperitoneally with thioacetamide (TAA) at 100/200 mg/kg from the first to the fifth week. Mice were intragastrically administrated with RK or Cur once a day from the second to the fifth week. In activated HSCs, RK inhibited extracellular matrix (ECM) accumulation, inflammation, and epithelial−mesenchymal transition (EMT) process. RK both activated FXR/PGC-1α and regulated their crosstalk, which were verified by their inhibitors and agonists. Deficiency of FXR or PGC-1α also attenuated the effect of RK on the reverse of activated HSCs. RK also decreased serum ALT/ AST levels, liver histopathological change, ECM accumulation, inflammation, and EMT in mice caused by TAA. Double activation of FXR/PGC-1α might be the key targets for RK against hepatic fibrosis. Above all, these discoveries supported the potential of RK as a novel candidate for the dietary intervention of hepatic fibrosis.

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“…Furthermore, it is noteworthy that activated CASP3 also plays a key role in the cleavage of PARP, another pivotal enzyme in the process of apoptosis. PARP, when cleaved by CASP3, loses its ability to repair DNA and maintain cell survival, thereby pushing the cell toward apoptosis [ 50 , 51 ]. Additionally, the tumor suppressor gene Tp53 acts as a proapoptotic factor and is triggered in response to cellular stresses, including oxidative stress [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models

Kim,

Lee,

Noh

et al. 2023

Antioxidants

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Liver fibrosis, defined by the aberrant accumulation of extracellular matrix proteins in liver tissue due to chronic inflammation, represents a pressing global health issue. In this study, we investigated the transcriptomic signatures of three independent liver fibrosis models induced by bile duct ligation, carbon tetrachloride, and dimethylnitrosamine (DMN) to unravel the pathological mechanisms underlying hepatic fibrosis. We observed significant changes in gene expression linked to key characteristics of liver fibrosis, with a distinctive correlation to the burn-wound-healing pathway. Building on these transcriptomic insights, we further probed the p53 signaling pathways within the DMN-induced rat liver fibrosis model, utilizing western blot analysis. We observed a pronounced elevation in p53 protein levels and heightened ratios of BAX/BCL2, cleaved/pro-CASPASE-3, and cleaved/full length-PARP in the livers of DMN-exposed rats. Furthermore, we discovered that orally administering oligonol—a polyphenol, derived from lychee, with anti-oxidative properties—effectively countered the overexpressions of pivotal apoptotic genes within these fibrotic models. In conclusion, our findings offer an in-depth understanding of the molecular alterations contributing to liver fibrosis, spotlighting the essential role of the apoptosis pathway tied to the burn-wound-healing process. Most importantly, our research proposes that regulating this pathway, specifically the balance of apoptosis, could serve as a potential therapeutic approach for treating liver fibrosis.

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Protective role of Siberian onions against toxin-induced liver dysfunction: an insight into health-promoting effects

Abstract: Siberian onion (SO) is a delicious wild vegetable. Its taste is most unique, not only like scallions, but also like leeks or garlic. It also has a traditional medicinal value...

Cited by 6 publications

References 39 publications

Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

Onion and Apple Functional Ingredients Intake Improves Antioxidant and Inflammatory Status and Vascular Injury in Obese Zucker Rats

Raspberry Ketone Attenuates Hepatic Fibrogenesis and Inflammation via Regulating the Crosstalk of FXR and PGC-1α Signaling

Integrative Transcriptomic Analysis Reveals Upregulated Apoptotic Signaling in Wound-Healing Pathway in Rat Liver Fibrosis Models

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