Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats

Alshehri, Fahad S.; Alorfi, Nasser M.

doi:10.3389/fphar.2023.1130670

Cited by 2 publications

(1 citation statement)

References 114 publications

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“…It has been reported that carvacrol exhibits hepatoprotective activity by increasing the total antioxidant capacity (TAS), suppressing the increase in total oxidant capacity (TOS) and MDA ( Mohseni et al, 2020 ). It has been reported that carvacrol has hepatoprotective properties by suppressing the expression of TNF-α, interleukin-6, and NF- κB ( Aristatile et al, 2013 ; Alshehri and Alorfi, 2023 ). Again, carvacrol has been documented to prevent the increase in liver function tests with ethanol ( Khan et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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Background: Acrylamide causes hepatotoxicity with the effect of oxidative stress and inflammatory processes. Carvacrol is a monoterpenic phenol with antioxidant and anti-inflammatory properties.Aims: To determine the effects of carvacrol on oxidative liver injury induced by acrylamide administration in rats.Methods: Rats were divided into three groups of six animals each: healthy group acrylamide group (ACR), and acrylamide + carvacrol group (TACR). First, carvacrol (50 mg/kg) was administered intraperitoneally to the CACR group. One hour later, acrylamide (20 mg/kg) was given orally to the ACR and CACR groups. This procedure was performed for 30 days, after which the animals were sacrificed. The malondialdehyde (MDA) and total glutathione (tGSH) levels, total oxidant (TOS) and total antioxidant status (TAS), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and nuclear factor kappa b (NF-κB) were measured in the excised liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in blood serum samples. Liver tissues were also examined histopathologically.Results: In the ACR group, malondialdehyde, TOS, ALT, AST levels, and NF-κB, IL-1β, and TNF-α levels were found to be high, and tGSH and total antioxidant status levels were low. In addition, diffuse degenerative changes and necrosis in hepatocytes, and moderate inflammation in the portal region were detected in the liver tissues of the ACR group. While carvacrol prevented the biochemical changes induced by acrylamide, it also alleviated the damage in the histological structure.Conclusion: Carvacrol may be used for liver damage caused by acrylamide.

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Section: Introductionmentioning

confidence: 99%

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

et al. 2023

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Effects of Long-Term High-Ergosterol Intake on the Cholesterol and Vitamin D Biosynthetic Pathways of Rats Fed a High-Fat and High-Sucrose Diet

Kuwabara,

Sato,

Nakagawa

2023

Biological & Pharmaceutical Bulletin

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Dyslipidemia is a lifestyle-related (physical inactivity or obesity) disease; therefore, dietary foods that can easily be consumed in daily life is important to prevent dyslipidemia. Ergosterol, a precursor of vitamin D2, is a fungal sterol present in the membranes of edible mushrooms and other fungi. Ergosterol is converted to brassicasterol by 7-dehydrocholesterol reductase (DHCR7), a cholesterol biosynthesis enzyme that converts 7-dehydrocholesterol (a precursor of vitamin D3) into cholesterol.Previously, we reported that ergosterol increases 7-dehydrocholesterol, decreases cholesterol levels by competitive effect of DHCR7, and reduces DHCR7 mRNA and protein levels in human HepG2 hepatoma cells. Here, we investigated the effects of long-term high ergosterol intake on the cholesterol, vitamin D2, and D3 biosynthetic pathways of rats fed a high-fat and high-sucrose (HFHS) diet using gas chromatography-mass spectrometry and liquid chromatography with tandem mass spectrometry. In HFHS rats, oral ergosterol administration for 14 weeks significantly decreased plasma low-density lipoprotein cholesterol, total bile acid, and cholesterol precursor (squalene and desmosterol) levels and increased 7-dehydrocholesterol levels compared to HFHS rats without ergosterol. Ergosterol, brassicasterol, and vitamin D2 were detected, cholesterol levels were slightly decreased, and levels of vitamin D3 and Biological and Pharmaceutical Bulletin Advance Publication its metabolites were slightly increased in rats fed HFHS with ergosterol. These results showed that ergosterol increased vitamin D2 levels, inhibited the cholesterol biosynthetic pathway, and possibly promoted vitamin D3 biosynthesis in vivo.Therefore, daily ergosterol intake may aid in the prevention of dyslipidemia.

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Protective role of resveratrol against VCM-induced hepatotoxicity in male wistar rats

Cited by 2 publications

References 114 publications

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats

Effects of Long-Term High-Ergosterol Intake on the Cholesterol and Vitamin D Biosynthetic Pathways of Rats Fed a High-Fat and High-Sucrose Diet

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