Protective Role of MAVS Signaling for Murine Lipopolysaccharide-Induced Acute Kidney Injury
Trang Anh Thi Tran,
Yasunori Iwata,
Linh Thuy Hoang
et al.
Abstract:Despite treatment advances, acute kidney injury (AKI)–related mortality rates are still high in hospitalized adults, often due to sepsis. Sepsis and AKI could synergistically worsen the outcomes of critically ill patients. TLR4 signaling and mitochondrial antiviral signaling protein (MAVS) signaling are innate immune responses essential in kidney diseases, but their involvement in sepsis-associated AKI (SA-AKI) remains unclear. We studied the role of MAVS in kidney injury related to the TLR4 signaling pathway … Show more
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