Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis

Effect of Luteolin on the Levels of Glycoproteins During Azoxymethane-induced Colon Carcinogenesis in Mice

“…Carbohydrates moieties of glycoproteins have also been implicated in the transport of metabolites across cell membranes and also observed a direct relationship between glycoproteins and tumorigenesis (Femia et al, 2004). Previous studies from our laboratory, showed LUT decreases the incidence of aberrant crypt foci (Ashokkumar & Sudhandiran, 2008), reduces the tumor formation and inhibits the cell proliferation via Wnt/β-catenin mediated pathway (Ashokkumar & Sudhandiran, 2011) In the present study, evaluates the modulating effect of LUT on MDF, glycoconjugates and lipid peroxidation in AOM-induced colon cancer.…”

“…Luteolin administration restored the lipid peroxidation levels, which may be due to the anti-oxidant activity of luteolin (Samy et al, 2006;Ashokkumar & Sudhandiran, 2008).…”

Signal Transducer and Activator of Transcription 3 - A Promising Target in Colitis-Associated Cancer

“…In addition, AOM-induced CRC appears to follow the concept in which tumor initiation is followed by tumor promotion and progression in a sequential manner. Specifically, AOM induces the onset of ACF, as the precursor lesion and Mucin depleted foci (Ashokkumar and Sudhandiran, 2008;Norazalina et al, 2010;Pandurangan et al, 2012) followed by the onset of adenocarcinoma (Ashokkumar and Sudhandiran, 2011;Shafie et al, 2013) most often of the distal colon, and, finally, metastasis to mesenteric lymph nodes and liver (Reddy, 2004).…”

“…Despite of the familial basis of CRC, environmental factors such as food-borne mutagens, chronic intestinal inflammation, specific intestinal commensals and pathogens, leads development of CRC. Chemically-induced cancer models are very useful in understanding the consequences of colon cancer in rodents (Ashokkumar and Sudhandiran, 2008;Pandurangan et al, 2012;Pandurangan et al, 2013;Shafie et al, 2013). A myriad of signaling events were altered during the progression of the colon cancer was reported (Pandurangan, 2013).…”

Luteolin Induced-growth Inhibition and Apoptosis of Human Esophageal Squamous Carcinoma Cell Line Eca109 Cells in vitro

“…Luteolin, 3',4',5,7-tetrahydroxyflavone, is a common dietary flavonoid can be found in avariety of vegetables, fruits, and medicinal herbs (Sasaki et al, 2003). Luteolin has been shown to possess multiple biological activities such as anti-inflammation, anti-oxidant and anti-cancer (Ashokkumar et al, 2008;Park et al, 2012). Among these activities, the anti-cancer effect of luteolin has been studied in vitro.…”