Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide

Spasojević, Ivan; Bajić, Aleksandar; Jovanović, Katarina; Spasić, Mihajlo; Anđjus, Pavle R.

doi:10.1016/j.carres.2009.05.023

Cited by 28 publications

(43 citation statements)

References 42 publications

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“…16 The reducing sugars, due to the same capacity, could also display antioxidant activity. 17 Different health benets of polyunsaturated fatty acids (PUFA) have also been described. For example, it was reported that PUFA could be used to sensitize breast cancer cell lines and mammary tumors to anticancer drugs, increasing survival and chemotherapy efficacy.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and phytochemical characterization of Arenaria montana L.

et al. 2014

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The bioactivity (antioxidant and cytotoxic activities) of the aqueous and methanolic extracts of Arenaria montana L., a plant commonly used in Portuguese folk medicine, was evaluated and compared.Furthermore, the phytochemical composition was determined based on hydrophilic (sugars, organic acids and phenolic compounds) and lipophilic (fatty acids and tocopherols) compounds, in order to valorize this plant material as a functional food/nutraceutical. Fructose, oxalic acid, methyl-luteolin 2 00 -O-feruloylhexosyl-C-hexoside, a-tocopherol, and linoleic acid were the main individual compounds found in A. montana. In general, the aqueous extract showed higher antioxidant and cytotoxic activities than the methanolic extract; the latter showed activity only against HeLa and HepG2 cell lines. Both aqueous and methanolic extracts showed some hepatotoxicity but at higher doses than the ones active for tumor cell lines. Moreover, the aqueous extract of A. montana may be used as a functional food or nutraceutical due to the high antioxidant and cytotoxic activities, and due to the presence of bioactive compounds. As far as we know, this is the first report on the phytochemical composition and bioactivity of A. montana.

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Section: Introductionmentioning

confidence: 99%

Bioactivity and phytochemical characterization of Arenaria montana L.

et al. 2014

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“…Проте штам, де-фектний за супероксидисмутазою, демонструє вміст α-дикарбонільних сполук нижчий у 1,4 і 1,8 раза, ніж вихідний штам відповідно за умов контролю та стресу. Оскільки чутливість організмів може бути різною до того самого чинника за хронічного та гострого стресу [3,9,[11][12][13], на наступно-му етапі ми дослідили як впливає інкубація з 50 мм гліоксалем протягом 1 год (го-стрий стрес) на дріжджі, які вирощували за контрольних умов до стаціонарної фази. Рис.…”

Section: рис 3 вміст карбонільних груп протеїнів (а) та α-дикарбоніunclassified

“…Водночас, частково розщеплюючись у живих організмах, продукти неензиматичного глікозилювання часто є джерелом АКС і АФК, замикаючи, так зване, хибне коло глікації і вільнорадикального окислення, що призво-дить до розвитку карбонільного/оксидатив-ного стресу [3,9]. В залежності від тривалості впливу факторів розрізняють хронічний та го-стрий стрес, відповідь організмів на які іноді суттєво відрізняється [3,9,[11][12][13].…”

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Defects in antioxidant defence enhance glyoxal toxicity in the yeast Saccharomyces cerevisiae

Semchyshyn¹

2013

Ukr.Biochem.J.

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“…However, short-term application of fructose demonstrated better protective action against oxidative stress than glucose (Spasojević et al, 2009a;2009b). It was suggested that any excess of fructose should be eliminated from normal diets.…”

Section: Reactive Carbonyl and Oxygen Species Are Potential Aging Andmentioning

confidence: 99%

“…It was suggested that any excess of fructose should be eliminated from normal diets. On the other hand, short-term acute application of fructose has protective effects under pathophysiological conditions related to oxidative stress (Spasojević et al, 2009a;2009b).…”

Section: Reactive Carbonyl and Oxygen Species Are Potential Aging Andmentioning

confidence: 99%

Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection

Semchyshyn¹,

Lushchak²

2012

Oxidative Stress - Molecular Mechanisms and Biological Effects

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Protective role of fructose in the metabolism of astroglial C6 cells exposed to hydrogen peroxide

Cited by 28 publications

References 42 publications

Bioactivity and phytochemical characterization of Arenaria montana L.

Bioactivity and phytochemical characterization of Arenaria montana L.

Defects in antioxidant defence enhance glyoxal toxicity in the yeast Saccharomyces cerevisiae

Interplay Between Oxidative and Carbonyl Stresses: Molecular Mechanisms, Biological Effects and Therapeutic Strategies of Protection

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