Protective role of folic acid in thyroxine-induced cardiac hypertrophy in hyperthyroid rat

Tousson, Ehab; Hafez, Ezar; Massoud, Ahmed; Sweef, Osama; Atta, Nermin

doi:10.1016/j.biomag.2013.03.001

Cited by 9 publications

(10 citation statements)

References 32 publications

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“…On the other hand; in order to ensure the hyperthyroid state we regularly determined the serum T 3 , T 4 and TSH where serum T 3 and T 4 concentrations is significantly elevated and serum TSH concentration is depressed in rats receiving L-Thyroxin sodium-induced hyperthyroidism. In the present study; TSH were significantly increase in hypothyroid and significantly decrease in hyperthyroid rats; this result coincides with studies of Shibutani et al (2009); Ibrahim et al (2011Ibrahim et al ( , 2012; Tousson et al (2011aTousson et al ( , 2013Tousson et al ( , 2014a; Hafez and Tousson (2014).…”

Section: Discussionsupporting

confidence: 93%

“…The previous studies indicate that hypo and hyperthyroidism causes oxidative tissue damage by increasing lipid peroxidation in tissues and decreasing the level of antioxidant enzymes (Ibrahim et al, 2012;Ali et al, 2013;Salama et al, 2013;Tousson et al, 2012bTousson et al, , 2012cTousson et al, , 2013. In the current study; spleen in both hypothyroid and hyperthyroid rats revealed many of abnormalities as marked disruption of spleen structure, loss in distinction between the white and red pulps, degeneration and vacuolation with an increased in the lymphocyte population and in the number of inflammatory cell components.…”

Section: Discussionmentioning

confidence: 98%

“…The present study was designed to investigate the effect of thyroid dysfunctions (hypothyroidism and hyperthyroidism) and apoptotic markers (P53, Bcl2 and Caspase 3 immunoreactivities) on rat spleen. In order to achieve this target we made a hypothyroid state by using a reversible PTU (Tousson et al, 2012a(Tousson et al, , 2012c and we made a hyperthyroid state by using L-Thyroxin sodium administration (Tousson et al, 2013). PTU has been used as an anti-thyroid agent, because of its specific and wellcharacterized mode of action (Gilbert and Paczkowski, 2003;Ahmed et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Group 3: Hyperthyroid group in which a chemical experimental rat model of hyperthyroidism that mimics hyperthyroidism in humans has been developed. Rats received L-Thyroxin sodium administration (100 µg/Kg, GSK Pharmaceutical Chemicals Co., USA) in drinking water for 6 weeks (Tousson et al, 2013).…”

Section: Experimental Animals and Study Designmentioning

confidence: 99%

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Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

Hafez

Masoud

Barnous

et al. 2015

Journal of Bioscience and Applied Research

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Apoptosis plays a critical role in the development and homeostasis of multicellular organisms, especially those with high cell turnover such as the lymphoid system. The current study aimed to examined the effects of changes in thyroid hormones on apoptosis of spleen in male rats. 30 rats were equally divided into three groups (10 animals each). G 1 , control group in which animals did not received any treatment; G 2 , Hypothyroid group in which rats received 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 6 weeks; G 3 , Hyperthyroid group in which rats received 100 µg/Kg L-Thyroxin sodium administration in drinking water for 6 weeks. In the present study; serum T 3 and T 4 concentrations were depressed and serum TSH concentration was significantly elevated in rats receiving PTU-induced hypothyroidism. On the other hand; serum T 3 and T 4 concentrations were significantly elevated and serum TSH concentration was depressed in rats receiving L-Thyroxin sodium-induced hyperthyroidism. In the current study; spleen in both hypothyroid and hyperthyroid rats revealed many of abnormalities as marked disruption of spleen structure, loss in distinction between the white and red pulps, degeneration and vacuolation with an increased in the lymphocyte population. Also, a significant increase in p53 and Caspase3 apoptotic cells and a significant decrease in Bcl-2 antiapoptotic cells in the spleen tissues revealed the possibility of the apoptosis occurrence after PTU or Thyroxin administration in the case of hypothyroidism and hyperthyroidism.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Animals and Study Designmentioning

confidence: 99%

See 2 more Smart Citations

Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

Hafez

Masoud

Barnous

et al. 2015

Journal of Bioscience and Applied Research

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“…Additionally, complex changes in folic acid metabolism occur in thyroid dysfunction with increases in tetrahydrofolate and decreases in methyltetrahydrofolate in hypothyroid rat liver [9]. Alteration in thyroid hormone level is also known to modulate functions of several tissues in adult animals by modulating their antioxidant defenses [4][5][6][7][8][10][11][12][13]. Overt Thyroid dysfunctions are frequently associated with abnormalities of biochemical liver tests and in severe forms with histologically evident hepatocellular damage the activity of hepatic lipase is decreased [14].…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Alleviates Oxidative Stress and Hyperhomocysteinemia Involved in Liver Dysfunction of Hypothyroid Rats

Tousson¹,

Ibrahim²,

Salama³

et al. 2014

AJBR

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Thyroid hormones are essential for growth and development of the liver. This study evaluated some biochemical alterations in post-pubertal hypothyroidism and its impact on liver functions. Additionally, the ameliorating role of folic acid supplementation was investigated. Fifty male albino rats were randomly divided into five groups (group I, control; group II, folic acid; group III, 0.05% propylthiouracil-induced hypothyroid rats; group IV, Co-treatment; group V post-treatment). There was a significant decrease in plasma T 3 , body weight, fluid and food intakes, folic acid, ALT, total thiol and tFRAP in hypothyroid rats as compared to control group. On the other hand, a significant increase in TSH, relative liver weight, plasma of total homocysteine, serum total protein, AST, total serum bilirubin, cholesterol and tMDA in hypothyroid rats as compared to control group. This reflects hyperhomocysteinemia and oxidative stress associated with hypothyroid state. Folic acid supplemented after restoration of the euthyroid state presented better amelioration over its concurrent supplementation. If confirmed in human beings, our results could propose that folic acid can be used as an adjuvant therapy in hypothyroidism disorders with thyroxin replacement therapy.

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Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice

Alotaibi

Tousson

El‐Masry

et al. 2020

Environmental Toxicology

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While clinical innovation has improved, cancer or malignant growth stays a genuine medical issue and has been perceived as a significant factor in mortality and morbidity. Current work aimed to define the cardiac defensive effects of curcumin nanoparticles (Cur Nps) against EAC induced cardiac toxicity, injury, and alterations in apoptosis, proliferation, and cytokines immunoreactivity. Forty female mice were aimlessly and equally divided into four groups [Gp1, Control; Gp2, Cur NPs; Gp3, Ehrlich ascites carcinoma (EAC); Gp4, Co-treatment of EAC with Cur NPs (Cur NPs + EAC)]. Serum lactate dehydrogenase (LDH), phosphocreatine kinase (CPK), creatine kinase myoglobin (CK-MB), alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), cholesterol, triglycerides, potassium ions, cardiac injury, P53, vascular endothelial growth factor protein (VEGF), Bax, and tumor necrosis factor alpha (TNFα) expressions were significantly elevated while sodium ions levels were significantly depleted in EAC when compared to control. Co-treatment of EAC with Cur NPs (Cur NPs + EAC) improved these parameters as compared with EAC group. So, our results indicate that; Cur NPs induced protection to the blood and heart tissue during Ehrlich ascites carcinoma.

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Protective role of folic acid in thyroxine-induced cardiac hypertrophy in hyperthyroid rat

Cited by 9 publications

References 32 publications

Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

Folic Acid Alleviates Oxidative Stress and Hyperhomocysteinemia Involved in Liver Dysfunction of Hypothyroid Rats

Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice

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