Protective role of flax lignans against lead acetate induced oxidative damage and hyperlipidemia in rats

Newairy, Al-Sayeda A.; Abdou, Heba M.

doi:10.1016/j.fct.2009.01.012

Cited by 109 publications

(76 citation statements)

References 50 publications

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“…These results are in agreement with previous reports (Flora et al, 2007;Newairy and Abdou, 2009). The decrease in GPX level in the liver with lead acetate exposure could be due to lead's displacement of the selenocysteine group from the active site in the liver tissue.…”

Section: Discussionsupporting

confidence: 83%

“…GST is also neutralizing oxidative molecules like ROS. The significant reduction in GST levels observed after lead acetate exposure could be due to lead acetate affects on sulfhydryl groups as lead is known to be able to bind irreversibly with -SH groups on proteins, rendering them useless (Mudipall, 2007;Flora et al, 2007;Gurer and Ercal, 2000;Hsu and Guo, 2002;Newairy and Abdou, 2009).…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

et al. 2010

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-Lead is known to disrupt the biological systems by altering the molecular interactions, cell signaling, and cellular function. Exposure to even low levels of lead may have potential hazardous effects on brain, liver, kidneys and testes. The efficacy of Etlingera elatior (torch ginger) to protect hepatotoxicity induced by lead acetate was evaluated experimentally in male Sprague -Dawley rats. Rats were exposed to lead acetate in drinking water (500 ppm) for 21 days and the effects of concurrent treatment with extract of E. elatior on hepatic lipid hydroperoxides (LPO), protein carbonyl content (PCC), total antioxidants (TA), superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione STransferase (GST) levels and histopathological changes in liver were evaluated. There was a significant decrease in TA and other antioxidant enzymes (p < 0.05) and increase in LPO and PCC (p < 0.05) with lead acetate ingestion. Concurrent treatment with E. elatior extract significantly reduced the LPO and PCC (p < 0.05) in serum and increased the antioxidant enzyme levels (p < 0.05) in the liver. Significant histopathological changes were seen in hepatic tissue with chronic lead ingestion. Treatment with E. elatior significantly reduced these lead-induced changes in hepatic architecture. E. elatior has also reduced the blood lead levels (BLL). Thus, there has been extensive biochemical and structural alterations indicative of liver toxicity with exposure to lead and E. elatior treatment significantly reduced these oxidative damage. Our results suggest that E. elatior has a powerful antioxidant effect against lead-induced hepatotoxicity.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

et al. 2010

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“…Further, our findings on lipid profile and biochemical parameters indicative of liver functions reveal a modulatory effect of lead exposure to the rats which was restored by the bromelain treatment. Several studies have incriminated lead exposure to lipid abnormalities and risk of atherosclerosis [17]. However, effect of Pb exposure on the lipid profile has variable effects as evident from previous reports [3].…”

Section: Discussionmentioning

confidence: 86%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

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The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.

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“…23 Protective role of flax lignans against lead acetate induced oxidative damage and hyperlipidemia in rat. 24 This can help enhance the biologically active lignans such as SDG through biotechnological route, which can help in making the flaxseed more popular as a nutraceuticals, functional and a prophylactic, as it is already known for its utility in conventional food. It can also help in different diseases in humans related to stress or free radicals and can be examined in individual diseases for the best suitability as therapeutic or prophylactic.…”

Section: Discussionmentioning

confidence: 99%

Hepato-protective Potential of Hull Fraction from Indian Flaxseed Cultivar

et al. 2011

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Objective: Secoisolariciresinol diglucoside (SDG) isolated from hull fraction of Indian flaxseed cultivar was studied for its hepatoprotective potential by measuring the level of hepatic enzymes such as catalase, peroxidase and superoxide desmutase (SOD) upon feeding to albino rats. Material & Methods:The animals were grouped into five groups (n=5): The first group served as normal and received normal diet without treatment of toxin and hull fraction of flaxseed. The second group was named the control and received a regular commercial diet. The third, fourth and fifth groups were fed with normal diet and supplemented with hull fraction of flaxseed (150 and 250 μg/kg) and standard SDG (150 μg/kg), that was mixed with olive oil for 14 days.Results: Pretreatment of rats with 150 µg/kg b.w hull fraction of flaxseed followed by CCl4 treatment caused restoration of catalase, SOD and peroxidase by 37.70%, 108.22% and 23.89% respectively as compared to control. The group treated with 250 µg/kg b.w hull fraction of flaxseed showed the restoration of 67.30%, 152.82% and 39.88% of catalase, SOD and peroxidase, respectively. Conclusion:In conclusion, SDG fed in the form of flaxseed hull is responsible for its hepatoprotective properties. Further, it can be used as a potential source of nutraceutical agent and studies are required in this field to examine its use in large scale for food and feed industries.

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Protective role of flax lignans against lead acetate induced oxidative damage and hyperlipidemia in rats

Cited by 109 publications

References 50 publications

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

Protective effect of Etlingera elatior (torch ginger) extract on lead acetate - induced hepatotoxicity in rats

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Hepato-protective Potential of Hull Fraction from Indian Flaxseed Cultivar

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