Protective role of Ficus benghalensis against isoniazid-rifampicin induced oxidative liver injury in rat

Parameswari, S Angala; Saleem, Tayyaba; Chandrasekar, Kirubhanand; Chetty, C. Madhusudhana

doi:10.1590/s0102-695x2012005000009

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…The fruits were traditionally used in folk medicine for respiratory disorders and certain skin diseases. The phytoconstituents present in F. benghalensis (Aerial root) revealed significant hepatoprotective activity against isoniazid-rifampicin induced oxidative liver injury in rats, along with free radical scavenging effect, which may be attributed to their polyphenolic compounds including flavonoids and terpenoids, which are similar to the report as described by Parameswari et al 2012 [34]. Along with bark have also demonstrated promising results in CCl 4 and Paracetamol induced model of hepatotoxicity, as explained and elaborated by Baheti, and Goyal 2011 [35].…”

Section: Discussionsupporting

confidence: 83%

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Karmakar

Sauseng²,

Biswas

et al. 2020

Clin Phytosci

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Background Trend analysis, graphical representation, and summarization of pharmacological research trends were carried out to act as guidance for the future. The main objectives of the research are to find out the complete research trend on the national tree of India so far and to validate its traditional uses along with the pharmacological hepatoprotective activity of Ficus benghalensis L. by developing three in vitro experimental models. Methods The fruit of the said plant (F. benghalensis) was extracted with different solvent (petrochemical ether, chloroform, ethyl acetate, ethanol, water) system and the yield value was determined. Phytochemical screening was also done with a different solvent. In an in-vitro study, the liver of freshly slaughtered goat (Capra Capra) was used for various investigational tests, and the hepatotoxicity was induced by carbon tetrachloride (CCl4) at a dose of 2 ml/kg, Acetaminophen at a dose of 7 g/kg, and with Erythromycin at a dose of 1.4 g/kg. The ethanol extract of fruits of F. benghalensis at the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg were used to observe its hepatoprotective effect against drug/chemical-induced in vitro hepatotoxicity as the model developed here with against a standard molecule, Silymarin. Results Amongst all solvents, ethanol was considered to be a universal solvent and resulted in a yield of 2.96%, which is maximum. Phytochemical screening of ethanol extract of fruit also showed the presence of alkaloids, steroids, flavonoids, carbohydrates, and glycosides. The protein concentration of liver homogenate based on comparison with standard protein concentration was found to be 1.6 mg/mL as measured at λmax of 750 nm. About the protein concentration, catalase (enzymatic) activity was also measured using the standard curve of H2O2, to calculate the specific activity of different models to compare the study results. Conclusion The significant effect of the reduction of hepatotoxicity was found at a dose of 500 mg/kg of fruit extract against Silymarin. Evaluation of Hepatoprotective activity of fruit in terms of catalase activity with different models flourishing the new research scope to fulfill the shortage of availability of a new, efficient, safe hepatoprotective agent in upcoming days. Graphical abstract

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Section: Discussionsupporting

confidence: 83%

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Karmakar

Sauseng²,

Biswas

et al. 2020

Clin Phytosci

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“…A combination of INH and rifampicin were used as inducers of liver damage [5,12], and silymarin was used as the reference hepatoprotective drug. The drug combination was administered orally 1 h before extract administration.…”

Section: Methodsmentioning

confidence: 99%

“…All pictures are magnified 10×10 times. ( a ) Normal control group; ( b ) Histology of the normal liver structure from literature [14]; ( c ) Positive control group; ( d ) Histology of the intoxication liver structure from literature [12]; ( e ) Group treated with extract at a dose of 50 mg/kg bw and ( f ) 100 mg/kg bw; and ( g ) The reference group. VS marks the central vein, yellow marks show normal hepatocytes, green marks show Kupffer cells, black marks show sinusoid dilatation, blue marks show hydropic degeneration, and orange marks show necrotic cells.…”

Section: Figurementioning

confidence: 99%

Effect of Vernonia amygdalina Del. Leaf Ethanolic Extract on Intoxicated Male Wistar Rats Liver

2017

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Vernonia amygdalina has been shown to have antioxidant activity, and is also expected to have hepatoprotective activity. This study was conducted to study the effect of V. amygdalina ethanol extracts on intoxicated rat livers. Fresh leaves were extracted in ethanol, and the hepatoprotective activity was tested on male Wistar rats induced with a combination of isoniazid (INH) and rifampicin. Parameters observed were the activity of the enzyme alanine transferase (ALT), serum albumin levels, liver index, and histopathological of the rat liver. The results showed that 50 and 100 mg/kg rat body weight of V. amygdalina ethanol extracts could prevent liver intoxication, starting on day 14. Based on serum albumin concentrations and ALT activity, the high dose extract (100 mg/kg) was more potent as a hepatoprotective agent compared to the extract at a low dose (50 mg/kg). The group of rats treated with a high dose extract showed normal liver index compared to the positive control. Through histology examination, the liver of rats treated with a high dose extract (100 mg/kg) showed minimal liver cell structure damage, and showed similar patterns to the normal rat. Based on these results, it can be concluded that V. amygdalina ethanol extracts can be used to protect the liver in a combination of INH and rifampicin as antituberculosis treatment.

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“…Moreover. Total protein and reduced glutathione levels were significantly (P<0.001) increased in treatment group 49 .…”

Section: Phytochemical Properties Of Ficus Benghalensismentioning

confidence: 90%

Untitled

2015

IJPSR

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Since, ancient time, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mention the use of plants in the treatment of various human ailments. Ficus benghalensis Linn is a large evergreen tree found throughout forest tracts of India. It is a popular indigenous system of medicine like Ayurveda, Siddha, Unani and Homeopathy. In the traditional system of medicine, various plants part such as stem bark, root bark aerial roots, vegetative bubs, leaves, fruits, and latex are used in dysentery, diarrhea, diabetes leucorrhoea, menorrhagia, nervous disorders, tonic and astringent. According to the ayurvedic system of medicine, Ficus benghalensis Linn. (Banyan tree) is well known to be useful in diabetes. The present review is, therefore, an effort to give a detailed survey of the literature on its pharmacognosy, phytochemistry, traditional and pharmacological uses. INTRODUCTION:Plants have been the primary source of drugs in medicine and another ancient system in the world. Herbalism is a traditional medicine or folk medicine practice based on the use of plant extracts 1 . Charaka Samhita and Sushrusha Samhita give an extensive description of various medicinal herbs. The genus Ficus includes some 750 species of plants occurring in most tropical and subtropical forests throughout the world. The genus is remarkable for the large in the habits of its species 2 . Many plants of this genus are used in medicine for the treatment of skin diseases, enlargement of liver and spleen, dysentery, diarrhea, diabetes, leprosy, lung complaints, leucorrhoea, heart diseases, cough, asthma, pills, ulcers, gonorrhea and rheumatism 3, 4 .

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Protective role of Ficus benghalensis against isoniazid-rifampicin induced oxidative liver injury in rat

Cited by 10 publications

References 20 publications

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

A pharmacological audit and advancement on the recent trend of research on Ficus benghalensis L. including its in vitro hepatoprotective activity

Effect of Vernonia amygdalina Del. Leaf Ethanolic Extract on Intoxicated Male Wistar Rats Liver

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