Protective role of Egyptian propolis against tumor in mice

El-Khawaga, Omali Y.; Salem, Tarek; Elshal, Mohamed F.

doi:10.1016/s0009-8981(03)00323-1

Cited by 51 publications

(37 citation statements)

References 17 publications

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“…Propolis widely began to attract the attention of scientists. The results of many animal researches showed that propolis may relieve the negative effects of oxidative stress on the body's defense system (El-Khawaga et al, 2003;Mannaa et al, 2011;Tatli Seven et al, 2012). Propolis protects the reproductive system from toxicity, especially flavonoids and phenolic compounds are responsible for antioxidant activity and show protective effects against aluminium chloride which caused testicular dysfunction, deterioration in semen quality and testosterone levels (Yousef and Salama, 2009;Ogretmen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Baykalır¹,

Seven²,

Gür³

et al. 2016

Anim Reprod

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This study was designed to determine the effects of propolis on the quality of sperm and reproductive organs in male rats treated with cyclosporine-A. In this study, 24 male Sprague-Dawley rats (280-300 g BW) at 8-10 weeks of age were used. The rats were randomly divided into control and 3 treatment groups. Each rat was placed into a cage. During 21 days (experimental period), Group 1 served as control group; Group 2 (CsA) was given 15 mg/kg BW/day of CsA by subcutaneously; Group 3 (P) was given 100 mg/kg BW/day of propolis by gavage; Group 4 (CsA+P) was given 15 mg/kg BW/day of CsA subcutaneously and 100 mg/kg BW/day of propolis by gavage. Administration of CsA to rats decreased sperm motility (P < 0.01) and sperm concentration (P < 0.01), and it increased total abnormal sperm rates (P < 0.05) as compared with the control group. Significant improvements were observed in the sperm motility (P < 0.01) and total abnormal sperm rates (P < 0.05) in CsA+P group. No significant differences were observed in the weights of right and left testes among all groups. The weight values of right and left epididymis were found similar to each other in CsA administrated groups. Seminal vesicle (P < 0.01) and prostat glands weights (P < 0.01) were significantly higher in CsA+P group than CsA group. As a result, it was determined that oral supplementation of 100 mg/kg of propolis had amendatory effect on the quality of sperm and reproductive organs treated with CsA administered rats. CsA treatment caused a significant increase in MDA level (P < 0.01) and significant decreases (P < 0.01) in GSH level and CAT activity when compared with the control group. Ingestion of propolis by CsA-treated rats significantly decreased the MDA level and significantly increased the GSH level when compared with the CsA alone group (P < 0.01).

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Section: Introductionmentioning

confidence: 99%

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Baykalır¹,

Seven²,

Gür³

et al. 2016

Anim Reprod

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“…In addition, propolis is known to be a health food that presents antibacterial, antioxidative, immunomodulatory, antifungal, antiviral, antiprotozoal, antiinflammatory and antitumor activities (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Bosio et al (13) Though the antibacterial activity of propolis essential oil from Paraná and Piauí states has been reported, the literature on the antimicrobial activity of this oil from Rio de Janeiro State is scarce (17,21).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of Brazilian propolis essential oil

Oliveira¹,

França²,

Kuster³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present study aimed at investigating the chemical composition of essential oil extracted from Brazilian propolis and the susceptibility of Staphylococcus aureus, Staphylococcus epidermides, Streptococcus pyogenes and Escherichia coli to this substance. The essential oil was obtained by steam distillation of propolis and examined by gas chromatography/mass spectrometry (GC/MS). In addition, the agar diffusion method using filter paper disks was employed. Antibacterial activity was measured as equivalent diameters of inhibition zones (in millimeters) after incubation at 37C for 24 hours. From the 26 identified constituents, β-caryophyllene (12.7%), acetophenone (12.3%) and β-farnesene (9.2%) were found to be major components. New components, namely linalool, methyl hydrocinnamate, ethyl hydrocinnamate, α-ylangene, γ-elemene and valencene, are reported for the first time to be present in propolis essential oil. This oil also exhibited antibacterial activity.

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“…Propolis and its active polyphenolic constituents have shown antibacterial (24), antioxidant (25), and prooxidant properties (26). Propolis also affects immunity (27,28) and acts against cell proliferation and tumors in vitro (29) and in vivo (30)(31)(32)(33).…”

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confidence: 99%

Radioprotective Effects of Quercetin and Ethanolic Extract of Propolis in Gamma-Irradiated Mice

Benković

Knežević

Đikić

et al. 2009

Archives of Industrial Hygiene and Toxicology

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The aim of this study was to assess radioprotective effects of quercetin and the ethanolic extract of propolis (EEP) in CBA mice exposed to a single radiation dose 4 Gy ( 60 Co). The mice were treated with 100 mg kg -1 quercetin or EEP a day for three consecutive days either before (pre-treatment) or after gamma-irradiation (therapy). Leukocyte count was determined in blood drawn from the tail vein, and DNA damage in leukocytes was assessed using the alkaline comet assay. Genotoxic effects of the test compunds were also evaluated in non-irradiated mice. The levels of radioprotection provided by both test compounds were compared with those established in mice that were given chemical radioprotector S-(2-Aminoethyl)isothiouronium bromide hydrobromide (AET). Mice that received pre-treatment were less sensitive to irradiation. Mice given the post-irradiation therapy showed a slight but not signifi cant increase in total leukocyte count over irradiated negative control. Quercetin showed better protective properties than EEP in both pre-treatment and therapy, and activated a higher number of leukocytes in non-irradiated mice. The alkaline comet assay suggests that both natural compounds, especially when given as pre-treatment, protect against primary leukocyte DNA damage in mice. At tested concentrations, EEP and quercetin were not genotoxic to non-irradiated mice. AET, however, caused a slight but not signifi cant increase in DNA damage. Although the results of this study show the radioprotective potential of the test compounds, further investigation is needed to clarify the underlying protection mechanisms.

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Protective role of Egyptian propolis against tumor in mice

Cited by 51 publications

References 17 publications

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

The effects of propolis on sperm quality, reproductive organs and testicular antioxidant status of male rats treated with cyclosporine-A

Chemical composition and antibacterial activity of Brazilian propolis essential oil

Radioprotective Effects of Quercetin and Ethanolic Extract of Propolis in Gamma-Irradiated Mice

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